CALR

CALR

Identifiers Symbols CALR; CRT; RO; SSA; cC1qR External IDs OMIM: 109091 MGI: 88252 HomoloGene: 37911 GeneCards: CALR Gene

Gene Ontology
Molecular function complement component C1q binding
DNA binding
mRNA binding
integrin binding
iron ion binding
calcium ion binding
protein binding
zinc ion binding
carbohydrate binding
ubiquitin protein ligase binding
peptide binding
hormone binding
protein binding involved in protein folding
androgen receptor binding
unfolded protein binding
chaperone binding
Cellular component acrosomal vesicle
proteinaceous extracellular matrix
extracellular space
intracellular
nucleus
cytoplasm
endoplasmic reticulum
endoplasmic reticulum lumen
Golgi apparatus
cytosol
polysome
external side of plasma membrane
cell surface
sarcoplasmic reticulum lumen
MHC class I peptide loading complex
perinuclear region of cytoplasm
integral to lumenal side of endoplasmic reticulum membrane
Biological process negative regulation of transcription from RNA polymerase II promoter
antigen processing and presentation of peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
peptide antigen assembly with MHC class I protein complex
regulation of transcription, DNA-dependent
protein folding
protein export from nucleus
cellular calcium ion homeostasis
activation of signaling protein activity involved in unfolded protein response
cell cycle arrest
spermatogenesis
positive regulation of cell proliferation
positive regulation of gene expression
negative regulation of translation
protein N-linked glycosylation via asparagine
protein maturation by protein folding
cortical actin cytoskeleton organization
endoplasmic reticulum unfolded protein response
response to estradiol stimulus
negative regulation of intracellular steroid hormone receptor signaling pathway
response to testosterone stimulus
protein localization to nucleus
regulation of meiosis
response to drug
antigen processing and presentation of exogenous peptide antigen via MHC class I
glucocorticoid receptor signaling pathway
regulation of apoptotic process
post-translational protein modification
cellular protein metabolic process
negative regulation of neuron differentiation
positive regulation of DNA replication
positive regulation of cell cycle
negative regulation of transcription, DNA-dependent
negative regulation of retinoic acid receptor signaling pathway
positive regulation of phagocytosis
protein stabilization
sequestering of calcium ion
cardiac muscle cell differentiation
cellular response to lithium ion
cellular senescence
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 811 12317 Ensembl ENSG00000179218 ENSMUSG00000003814 UniProt P27797 P14211 RefSeq (mRNA) NM_004343.3 NM_007591.3 RefSeq (protein) NP_004334.1 NP_031617.1 Location (UCSC) Chr 19:
13.05 – 13.06 Mb Chr 8:
84.84 – 84.85 Mb PubMed search

Calreticulin also known as calregulin, CRP55, CaBP3, calsequestrin-like protein, and endoplasmic reticulum resident protein 60 (ERp60) is a protein that in humans is encoded by the CALR gene.

Calreticulin is a multifunctional protein that binds Ca2+ ions (a second messenger in signal transduction), rendering it inactive. The Ca2+ is bound with low affinity, but high capacity, and can be released on a signal (see inositol triphosphate). Calreticulin is located in storage compartments associated with the endoplasmic reticulum.

The term "Mobilferrin" is considered to be the same as calreticulin by some sources.

Read more about CALR:  Function, Clinical Significance, Role in Cancer, Interactions