Bleomycin is a glycopeptide antibiotic produced by the bacterium Streptomyces verticillus. Bleomycin refers to a family of structurally related compounds. When used as an anticancer agent, the chemotherapeutical forms are primarily bleomycin A2 and B2. It works by causing breaks in DNA. The drug is used in the treatment of Hodgkin's lymphoma (as a component of the ABVD and BEACOPP regimen), squamous cell carcinomas, and testicular cancer, as well as in the treatment of plantar warts and as a means of effecting pleurodesis.
Read more about Bleomycin: History, Suppliers, Mechanism of Action, Biosynthesis, Side Effects
Other articles related to "bleomycin":
Chemotherapy Regimens - Common Chemotherapy Acronyms
... Components Example of uses, and other notes ABVD Adriamycin (doxorubicin), bleomycin, vinblastine, dacarbazine Hodgkin's lymphoma AC Adriamycin (doxorubicin), cyclophosphamide Breast cancer BEACOPP Bleomycin ...
... Components Example of uses, and other notes ABVD Adriamycin (doxorubicin), bleomycin, vinblastine, dacarbazine Hodgkin's lymphoma AC Adriamycin (doxorubicin), cyclophosphamide Breast cancer BEACOPP Bleomycin ...
Chemotherapy - Types - Cytotoxic Antibiotics
... idarubicin epirubicin, which also inhibit topoisomerase II other cytotoxic antibiotics bleomycin ... Bleomycin acts in unique way through oxidation of a DNA-bleomycin-Fe(II) complex and forming free radicals, which induce damage and chromosomal aberrations ...
... idarubicin epirubicin, which also inhibit topoisomerase II other cytotoxic antibiotics bleomycin ... Bleomycin acts in unique way through oxidation of a DNA-bleomycin-Fe(II) complex and forming free radicals, which induce damage and chromosomal aberrations ...
ABVD - Side Effects - Delayed Side Effects
... Pulmonary toxicity, or lung damage, can occur with the use of bleomycin in ABVD, especially when radiation therapy to the chest is also given as part ... damage in patients who have received bleomycin, even years later ... function tests are often used to assess for bleomycin-related damage to the lungs ...
... Pulmonary toxicity, or lung damage, can occur with the use of bleomycin in ABVD, especially when radiation therapy to the chest is also given as part ... damage in patients who have received bleomycin, even years later ... function tests are often used to assess for bleomycin-related damage to the lungs ...
BLMH
... Location (UCSC) Chr 17 28.58 – 28.62 Mb Chr 11 76.92 – 76.99 Mb PubMed search Bleomycin hydrolase is an enzyme that in humans is encoded by the BLMH gene ... Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution however, the only known activity of the enzyme is metabolic ...
... Location (UCSC) Chr 17 28.58 – 28.62 Mb Chr 11 76.92 – 76.99 Mb PubMed search Bleomycin hydrolase is an enzyme that in humans is encoded by the BLMH gene ... Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution however, the only known activity of the enzyme is metabolic ...
Bleomycin - Side Effects
... The most serious complication of bleomycin is pulmonary fibrosis and impaired lung function ... It has been suggested that bleomycin induces sensitivity to oxygen toxicity and recent studies support the role of the proinflammatory cytokines IL-18 and IL-1beta in the mechanism of bleomycin-induced lung injury ... Past history of treatment with bleomycin should therefore always be disclosed to the anaesthetist prior to undergoing a procedure requiring general ...
... The most serious complication of bleomycin is pulmonary fibrosis and impaired lung function ... It has been suggested that bleomycin induces sensitivity to oxygen toxicity and recent studies support the role of the proinflammatory cytokines IL-18 and IL-1beta in the mechanism of bleomycin-induced lung injury ... Past history of treatment with bleomycin should therefore always be disclosed to the anaesthetist prior to undergoing a procedure requiring general ...
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