BCR Gene

BCR Gene

Identifiers Symbols BCR; ALL; BCR1; CML; D22S11; D22S662; PHL External IDs OMIM: 151410 MGI: 88141 HomoloGene: 3192 ChEMBL: 5146 GeneCards: BCR Gene EC number 2.7.11.1

Gene Ontology
Molecular function protein serine/threonine kinase activity
protein tyrosine kinase activity
Rho guanyl-nucleotide exchange factor activity
GTPase activator activity
protein binding
ATP binding
phospholipid binding
kinase activity
Rac GTPase activator activity
Cellular component cytosol
plasma membrane
Biological process protein phosphorylation
signal transduction
small GTPase mediated signal transduction
brain development
actin cytoskeleton organization
negative regulation of cell migration
response to lipopolysaccharide
inner ear morphogenesis
negative regulation of neutrophil degranulation
negative regulation of inflammatory response
positive regulation of phagocytosis
neuromuscular process controlling balance
regulation of small GTPase mediated signal transduction
regulation of cell cycle
Sources: Amigo / QuickGO
Orthologs Species Human Mouse Entrez 613 110279 Ensembl ENSG00000186716 ENSMUSG00000009681 UniProt P11274 Q6PAJ1 RefSeq (mRNA) NM_004327.3 NM_001081412.2 RefSeq (protein) NP_004318.3 NP_001074881.1 Location (UCSC) Chr 22:
23.52 – 23.66 Mb Chr 10:
75.06 – 75.18 Mb PubMed search
Bcr-Abl oncoprotein oligomerisation domain
structure of the bcr-abl oncoprotein oligomerization domain
Identifiers
Symbol Bcr-Abl_Oligo
Pfam PF09036
InterPro IPR015123
Available protein structures:
Pfam structures
PDB RCSB PDB; PDBe
PDBsum structure summary

The breakpoint cluster region protein (BCR) also known as renal carcinoma antigen NY-REN-26 is a protein that in humans is encoded by the BCR gene. BCR is one of the two genes in the BCR-ABL complex, which is associated with the Philadelphia chromosome. Two transcript variants encoding different isoforms have been found for this gene.

Read more about BCR Gene:  Function, Clinical Significance, Structure, Interactions

Other articles related to "bcr gene, gene":

BCR Gene - Interactions
... BCR gene has been shown to interact with Abl gene, CD117, CRKL FES, Grb2, GRB10, HCK, MLLT4, PXN, PIK3CG, PTPN6, SOS1, and XPB ...