|Molecular function||• aminopeptidase activity
• metalloendopeptidase activity
• interleukin-6 receptor binding
• interleukin-1, Type II receptor binding
• tumor necrosis factor receptor binding
• protein binding
• metalloexopeptidase activity
• zinc ion binding
• metal ion binding
|Cellular component||• extracellular region
• endoplasmic reticulum
• endoplasmic reticulum lumen
• endoplasmic reticulum membrane
• integral to membrane
|Biological process||• angiogenesis
• antigen processing and presentation of peptide antigen via MHC class I
• membrane protein ectodomain proteolysis
• regulation of blood pressure
• response to bacterium
• antigen processing and presentation of endogenous peptide antigen via MHC class I
• regulation of innate immune response
• fat cell differentiation
• positive regulation of angiogenesis
|Sources: Amigo / QuickGO|
96.1 – 96.14 Mb
74.64 – 74.69 Mb
Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator, also known as ARTS-1, is a protein which in humans is encoded by the ARTS-1 gene.
ARTS1 is also known as:
- ER aminopeptidase 1 (ERAP1)
- ER aminopeptidase associated with antigen processing (ERAAP)
- Adipocyte-derived leucine aminopeptidase (ALAP)
- Puromycin-insensitive leucine aminopeptidase (PILS-AP)
Endoplasmic reticulum aminopeptidase 1 is active in the endoplasmic reticulum, which is involved in protein processing and transport. This protein is an aminopeptidase, which is an enzyme that cleaves other proteins into smaller fragments called peptides.
ERAP1 has two major functions in the immune system:
- First, ERAP1 cleaves several proteins called cytokine receptors on the surface of cells. Cleaving these receptors reduces their ability to transmit chemical signals into the cell, which affects the process of inflammation.
- Second, ERAP1 trims peptides within the endoplasmic reticulum so that they can be loaded onto major histocompatibility complex (MHC) class I. These peptides are attached to MHC class I in the endoplasmic reticulum and exported to the cell surface, where they are displayed to the immune system. If the immune system recognizes the peptides as foreign (such as viral or bacterial peptides), it responds by triggering the infected cell to self-destruct.
Other related articles:
... Aminopeptidases play a role in the metabolism of several peptides that may be involved in blood pressure and the pathogenesis of essential hypertension ... Mutations in the ARTS-1 have been linked to an increased risk of ankylosing spondylitis ...