Identifiers Symbols ERAP1; A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP; ERAAP1; PILS-AP; PILSAP External IDs OMIM: 606832 MGI: 1933403 HomoloGene: 56754 ChEMBL: 5939 GeneCards: ERAP1 Gene

Gene Ontology
Molecular function aminopeptidase activity
metalloendopeptidase activity
interleukin-6 receptor binding
interleukin-1, Type II receptor binding
tumor necrosis factor receptor binding
protein binding
metalloexopeptidase activity
zinc ion binding
metal ion binding
Cellular component extracellular region
endoplasmic reticulum
endoplasmic reticulum lumen
endoplasmic reticulum membrane
integral to membrane
Biological process angiogenesis
antigen processing and presentation of peptide antigen via MHC class I
membrane protein ectodomain proteolysis
regulation of blood pressure
response to bacterium
antigen processing and presentation of endogenous peptide antigen via MHC class I
regulation of innate immune response
fat cell differentiation
positive regulation of angiogenesis
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 51752 80898 Ensembl ENSG00000164307 ENSMUSG00000021583 UniProt Q9NZ08 Q9EQH2 RefSeq (mRNA) NM_001040458 NM_030711 RefSeq (protein) NP_001035548 NP_109636 Location (UCSC) Chr 5:
96.1 – 96.14 Mb Chr 13:
74.64 – 74.69 Mb PubMed search

Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator, also known as ARTS-1, is a protein which in humans is encoded by the ARTS-1 gene.

ARTS1 is also known as:

  • ER aminopeptidase 1 (ERAP1)
  • ER aminopeptidase associated with antigen processing (ERAAP)
  • Adipocyte-derived leucine aminopeptidase (ALAP)
  • Puromycin-insensitive leucine aminopeptidase (PILS-AP)

Endoplasmic reticulum aminopeptidase 1 is active in the endoplasmic reticulum, which is involved in protein processing and transport. This protein is an aminopeptidase, which is an enzyme that cleaves other proteins into smaller fragments called peptides.

ERAP1 has two major functions in the immune system:

  • First, ERAP1 cleaves several proteins called cytokine receptors on the surface of cells. Cleaving these receptors reduces their ability to transmit chemical signals into the cell, which affects the process of inflammation.
  • Second, ERAP1 trims peptides within the endoplasmic reticulum so that they can be loaded onto major histocompatibility complex (MHC) class I. These peptides are attached to MHC class I in the endoplasmic reticulum and exported to the cell surface, where they are displayed to the immune system. If the immune system recognizes the peptides as foreign (such as viral or bacterial peptides), it responds by triggering the infected cell to self-destruct.

Read more about ARTS-1:  Function, Clinical Significance

Other related articles:

ARTS-1 - Clinical Significance
... Aminopeptidases play a role in the metabolism of several peptides that may be involved in blood pressure and the pathogenesis of essential hypertension ... Mutations in the ARTS-1 have been linked to an increased risk of ankylosing spondylitis ...