Arsenic Toxicity - Oxidative Stress

Oxidative Stress

Studies have demonstrated that the oxidative stress generated by arsenic may disrupt the signal transduction pathways of the nuclear transcriptional factors PPAR’s, AP-1, and NF-κB, as well as the pro-inflammatory cytokines IL-8 and TNF-α. The interference of oxidative stress with signal transduction pathways may affect physiological processes associated with cell growth, metabolic syndrome X, glucose homeostasis, lipid metabolism, obesity, insulin resistance, inflammation, and diabetes-2. Recent scientific evidence has elucidated the physiological roles of the PPAR’s in the ω- hydroxylation of fatty acids and the inhibition of pro-inflammatory transcription factors (NF-κB and AP-1), pro-inflammatory cytokines (IL-1, -6, -8, -12, and TNF-α), cell4 adhesion molecules (ICAM-1 and VCAM-1), inducible nitric oxide synthase, proinflammatory nitric oxide (NO), and anti-apoptotic factors.

Epidemiological studies have suggested a correlation between chronic consumption of drinking water contaminated with arsenic and the incidence of Type 2-diabetes. The human liver after exposure to therapeutic drugs may exhibit hepatic non-cirrhotic portal hypertension, fibrosis, and cirrhosis. However, the literature provides insufficient scientific evidence to show cause and effect between arsenic and the onset of diabetes mellitus Type 2.

Read more about this topic:  Arsenic Toxicity

Other articles related to "oxidative stress, stress, oxidative":

Effects Of MDMA On The Human Body - Long-term Adverse Effects - Serotonergic Changes - Mechanisms of Serotonergic Changes
... proposed for this apparent neurotoxicity involves the induction of oxidative stress ... This stress results from an increase in free radicals and a decrease in antioxidants in the brain ... As the cell goes about its life, by-products called oxidative radicals are formed, also called free radicals ...
Discovery And Development Of Cyclooxygenase 2 Inhibitors - Cardiovascular Events Associated With Selective COX-2 Inhibitors - Possible Mechanisms
... rats (SHR) non-selective NSAIDs and the coxibs produce oxidative stress, indicated by enhanced vascular superoxide(O2-) content and elevated peroxide in plasma, which ... been hypothesized that depletion of BH4 can occur with excessive oxidative stress (that can be caused be NSAIDs) and, hence, be the cause of eNOS dysfunction ... is referred to as eNOS uncoupling, causes the production of O2- by eNOS, thereby leading to more oxidative stress produced by eNOS ...
Pathophysiology Of Chronic Fatigue Syndrome - Other Hypotheses - Oxidative Stress
... Oxidative stress, an imbalance between the production of reactive oxygen and a biological system's ability to readily detoxify the reactive intermediates or easily ... Gene expression studies suggest a common link between oxidative stress, immune system dysfunction and potassium imbalance in CFS patients leading to impaired nerve balance, reflected in abnormal heart rate ...
Arsenic Toxicity - Carcinogenicity
... Moreover, arsenic could cause oxidative stress by depleting the cell’s antioxidants, especially the ones containing thiol groups ... study indicates that methylation might in fact be a detoxification pathway with regard to oxidative stress the results showed that the lower the As methylation capacity was, the lower the level ... As reviewed by Kitchin (2001), the oxidative stress theory provides an explanation for the preferred tumor sites connected with arsenic exposure ...

Famous quotes containing the word stress:

    In the stress of modern life, how little room is left for that most comfortable vanity that whispers in our ears that failures are not faults! Now we are taught from infancy that we must rise or fall upon our own merits; that vigilance wins success, and incapacity means ruin.
    Agnes Repplier (1858–1950)