Antigen Processing


Antigen processing is a biological process that prepares antigens for presentation to special cells of the immune system called T lymphocytes. This process involves two distinct pathways for processing of antigens from an organism's own (self) proteins or intracellular pathogens (e.g. viruses), or from phagocytosed pathogens (e.g. bacteria); subsequent presentation of these antigens on class I or class II MHC molecules is dependent on which pathway is used. Both MHC class I and II are required to bind antigen before they are stably expressed on a cell surface.

While the conventional distinction between the two pathways is useful, there are instances where extracellular-derived peptides are presented in the context of MHC class I and cytosolic peptides are presented in the context of MHC class II (this often happens in dendritic cells).

Read more about Antigen ProcessingThe Endogenous Pathway, The Exogenous Pathway

Other articles related to "antigen processing, antigen, processing":

Antigen Processing - The Exogenous Pathway
... The exogenous pathway is utilized by specialized antigen presenting cells to present peptides derived from proteins that the cell has endocytosed ...
Polyclonal Response/GA2 - B Cell Response - Antigen Processing
... After recognizing an antigen, an antigen presenting cell such as the macrophage or B lymphocyte engulfs it completely by a process called phagocytosis ... Within the lysosome, the antigen is broken down into smaller pieces called peptides by proteases (enzymes that degrade larger proteins) ... in the lysosome – this method of "handling" the antigen is known as the exogenous or endocytic pathway of antigen processing in contrast to the endogenous or cytosolic pathway, which complexes the abnormal proteins ...
... membrane • cytosol • integral to membrane Biological process • angiogenesis • antigen processing and presentation of peptide antigen via MHC class I ... ARTS1 is also known as ER aminopeptidase 1 (ERAP1) ER aminopeptidase associated with antigen processing (ERAAP) Adipocyte-derived leucine aminopeptidase (ALAP) Puromycin-insensitive leucine ...
... binding • NF-kappaB binding Cellular component • cytoplasmic mRNA processing body • nucleus • nucleoplasm • cytoplasm • mitochondrion • cytosol • proteasome core complex ... function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides ...