AMPA

AMPA (2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid) is a compound that is a specific agonist for the AMPA receptor, where it mimics the effects of the neurotransmitter glutamate.

There are two types of Ionotropic glutamate receptors that are ligand gated ion channels whose agonists include AMPA, kainic acid and N-methyl--aspartic acid (NMDA). In the synapse, these two classes of receptors serve very different purposes. AMPA can be used experimentally to distinguish the activity of one receptor from the other in order to understand their differing functions. AMPA generates fast excitatory postsynaptic potentials (EPSP). AMPA activates AMPA receptors that are non-selective cationic channels allowing the passage of Na+ and K+ and therefore have an equilibrium potential near 0 mV.

Other articles related to "ampa":

Ca2+/calmodulin-dependent Protein Kinase - Long-Term Potentiation - Mechanistic Role in LTP
... Movement of AMPA receptors increases postsynaptic response to presynaptic depolarization through strengthening the synapses ... Mechanistically, CaMKII phosphorylates AMPA receptors at the P2 serine 831 site ... This increases channel conductance of GluA1 subunits of AMPA receptors, which allows AMPA receptors to be more sensitive than normal during LTP ...
Ampakines
... The ampakines take their name from the glutamatergic AMPA receptor with which they strongly interact ... The AMPA receptor, in turn, gets its name from AMPA, which selectively binds to it ...
GYKI-52,466
... receptor antagonist, which is a non-competitive AMPA receptor antagonist (IC50 values are 10-20, ~ 450 and >> 50 μM for AMPA-, kainate- and NMDA-induced responses respectively ... Like other AMPA receptor antagonists, GYKI-52466 has anticonvulsant and neuroprotective properties ...
Ampakine
... The ampakines take their name from the glutamatergic AMPA receptor with which they strongly interact ... The AMPA receptor, in turn, gets its name from AMPA, which selectively binds to it ...