Amenhotep I was the son of Ahmose I and Ahmose-Nefertari. His elder brothers, the crown prince Ahmose Sapair and Ahmose-ankh, died before him, thus clearing the way for his ascension to the throne. Amenhotep probably came to power while he was still young himself, and his mother, Ahmose-Nefertari, appears to have been regent for him for at least a short time. This is evidenced because both he and his mother are credited with opening a worker village at the site of Deir el-Medina. Amenhotep took his sister Ahmose-Meritamon as his Great Royal Wife. Another wife's name, Sitkamose, is attested on a nineteenth dynasty stele.
Beyond this, his relation to all other possible family members has been questioned. Ahhotep II is usually called his wife and sister, despite an alternate theory that she was his grandmother. He is thought to have had one son by Ahhotep II, Amenemhat, who died while still very young. This remains the consensus, although there are arguments against that relationship as well. With no living heirs, Amenhotep was succeeded by Thutmose I, whom he married to his sister, Aahmes, although once again there is no definite proof that the two were related. Since Aahmes is never called "King's Daughter" in any inscription, some scholars doubt this relation as well.
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