Identifiers Symbols ADH4; ADH-2 External IDs OMIM: 103740 MGI: 1349472 HomoloGene: 20162 ChEMBL: 2990 GeneCards: ADH4 Gene EC number

Gene Ontology
Molecular function NADPH:quinone reductase activity
alcohol dehydrogenase (NAD) activity
alcohol dehydrogenase activity, zinc-dependent
alditol:NADP+ 1-oxidoreductase activity
retinol dehydrogenase activity
all-trans retinal binding
zinc ion binding
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
benzaldehyde dehydrogenase activity
retinol binding
metal ion binding
NAD binding
Cellular component cytosol
microtubule cytoskeleton
Biological process retinoid metabolic process
alcohol metabolic process
ethanol oxidation
cellular aldehyde metabolic process
xenobiotic metabolic process
quinone cofactor metabolic process
retinol metabolic process
small molecule metabolic process
alcohol catabolic process
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 127 26876 Ensembl ENSG00000198099 ENSMUSG00000037797 UniProt P08319 Q9QYY9 RefSeq (mRNA) NM_000670 NM_011996 RefSeq (protein) NP_000661 NP_036126 Location (UCSC) Chr 4:
100.04 – 100.08 Mb Chr 3:
138.42 – 138.43 Mb PubMed search

Alcohol dehydrogenase 4 is an enzyme that in humans is encoded by the ADH4 gene.

This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes.