Acyl Carrier Protein

The acyl carrier protein (ACP) is an important component in both fatty acid and polyketide biosynthesis with the growing chain bound during synthesis as a thiol ester at the distal thiol of a 4'-phosphopantetheine moiety. The protein is expressed in the inactive apo form and the 4'-phosphopantetheine moiety must be post-translationally attached to a conserved serine residue on the ACP by the action of holo-acyl carrier protein synthase (ACPS), a phosphopantetheinyl transferase.

4'-Phosphopantetheine is an essential prosthetic group of several acyl carrier proteins involved in pathways of primary and secondary metabolism including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, and peptidyl carrier proteins (PCP) and aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). Phosphopantetheine fulfills two demands in these biosynthetic pathways. First, the intermediates remain covalently linked to the synthases (or synthetases) in an energy-rich linkage. Second, the flexibility and length of the phosphopantetheine chain (approximately 2 nm) allows the covalently tethered intermediates to have access to spatially distinct enzyme-active sites. This increases the effective molarity of the intermediate and allows an assembly line-like process.

The ACPs are small negatively charged α-helical bundle proteins with a high degree of structural and amino acid similarity. The structures of a number of acyl carrier proteins have been solved using various NMR and crystallography techniques.

The ACPs are related in structure and mechanism to the peptidyl carrier proteins (PCP) from nonribosomal peptide synthases.

Other articles related to "protein, acyl carrier protein, acyl carrier, acyl":

Lipoyl(octanoyl) Transferase
... is an enzyme that catalyzes the chemical reaction octanoyl- + protein protein N6-(octanoyl)lysine + acyl carrier protein Thus, the two substrates of this enzyme are ]] and protein ... The systematic name of this enzyme class is octanoyl-protein N-octanoyltransferase ... Other names in common use include LipB, lipoyl (octanoyl)--protein, N-lipoyltransferase, lipoyl (octanoyl)-acyl carrier proteinprotein transferase, lipoate/octanoate transferase, lipoyltransferase, octanoyl--protein N-oc ...
EC 1.8 - EC 1.3 Acting On The CH-CH Group of Donors - EC 1.3.1 With NAD or NADP As Acceptor
... EC fumarate reductase (NADH) EC meso-tartrate dehydrogenase EC acyl-CoA dehydrogenase (NADP+) EC enoyl-(acyl-carrier-protein) reductase (NADH ...
Beta-ketoacyl-(acyl-carrier-protein) Synthase III - Nomenclature
3-oxoacylACP synthase III, 3-ketoacyl-acyl carrier protein synthase III, KASIII, KAS III, FabH, β-ketoacyl-acyl carrier protein synthase III, β-ketoacyl-ACP synthase III, β-ke ...

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