Acute Hemolytic Transfusion Reaction - Pathophysiology

Pathophysiology

This may be caused by IgM Immunoglobulin anti A, anti B or both or by IgG Immunoglobulin or Rh, Kell, Duffy or other non ABO antibodies. The former results in a severe intravascular hemolysis and the later typically causes extravascular hemolysis. The reactions are mediated by cytokines like TNF, IL-8, monocyte chemoattractant protein, IL-1 etc.

  • Nonimmune mediated

These occur when RBCs are damaged before transfusion, resulting in hemoglobinemia and hemoglobinuria. Clinical symptoms are nil or milder

Read more about this topic:  Acute Hemolytic Transfusion Reaction

Other articles related to "pathophysiology":

University Of Ostrava - Faculties and Departments - Faculty of Medicine - Department of Physiology and Pathophysiology
... The Department of Physiology and Pathophysiology is divided into Institute of Physiology and Institute of Pathophysiology ... the Department of Physiology and Pathophysiology carries out scientific research and produces expert reports ...
Tension Headache - Cause
... of nitric oxide (NO) mechanisms suggest that NO may play a key role in the pathophysiology of CTTH ... spinal nucleus, thalamus, and cerebral cortex) is believed to be involved in the pathophysiology of chronic tension-type headache ... Moreover, a dysfunction in pain inhibitory systems may also play a role in the pathophysiology of chronic tension-type headache ...
Pathophysiology - Uses
... Pathophysiology is a required area of study for nearly all healthcare professional school programs (medical, dental, physician assistant, occupational therapy, physical therapy, nurse ...
Atrax Morgue - Partial Discography
... Texture (Cass) Slaughter Productions 1995 Pathophysiology (Cass) Old Europa Cafe 1995 Untitled (Cass) Slaughter Productions 1995 Autoerotic Death (Cass, Ltd) BloodLust ... CDr) Slaughter Productions 2002 La Casa Dalle Finestre Che Ridono (CDr) Slaughter Productions 2002 Pathophysiology (CDr) Transf/Order 2002 Sweetly (CDr, Album) Spatter ...