What is monoamine oxidase?

  • (noun): An enzyme that catalyzes the oxidation of many body compounds (e.g., epinephrine and norepinephrine and serotonin).
    Synonyms: MAO

Monoamine Oxidase

L-Monoamine oxidases (MAO) (EC 1.4.3.4) are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. The enzyme was originally discovered by Mary Bernheim in the liver and was named tyramine oxidase. They belong to the protein family of flavin-containing amine oxidoreductases.

Read more about Monoamine Oxidase.

Some articles on monoamine oxidase:

Monoamine Oxidase A - Aggression and The "Warrior Gene"
... A version of the monoamine oxidase-A gene has been popularly referred to as the warrior gene ... A connection between a version of the monoamine oxidase A gene (3R) and several types of antisocial behavior has been found ... Monoamine oxidases (MAOs) are enzymes that are involved in the breakdown of neurotransmitters such as serotonin and dopamine and are, therefore, capable of influencing feelings, mood, and behaviour of ...
Monoamine Oxidase B - Differences Between MAOA and MAOB
... In general, monoamine oxidase A (MAOA) prefers to metabolize norepinephrine (NE), serotonin (5-HT), and dopamine (DA) (and other less clinically relevant ... Monoamine oxidase B, on the other hand, prefers to metabolize dopamine (DA) (and other less clinically relevant chemicals) ... of the two enzymes are utilized clinically when treating specific disorders Monoamine oxidase A inhibitors have been used in the treatment of depression, and ...
Moclobemide - Pharmacology
... as a selective, reversible inhibitor of monoamine oxidase A (RIMA), a type of monoamine oxidase inhibitor (MAOI), and increases levels of norepinephrine (noradrenaline), dopamine, and especially serotonin ... vesicles extracellular levels also increase which results in increased monoamine receptor stimulation and suppression of REM sleep, down regulation of 3-adr ... Moclobemide increases levels of extracellular monoamines and decreases levels of their metabolites in rat brains tolerance to these effects does not seem to occur with chronic use of moclobemide ...
Monoamine Oxidase - Genetics
... A study based on the Dunedin cohort concluded that maltreated children with a low-activity polymorphism in the promoter region of the MAO-A gene were more likely to develop antisocial conduct disorders than maltreated children with the high-activity variant ... Out of the 442 total males in the study (maltreated or not), 37% had the low activity variant ...
Monoamine Oxidase B
... Monoamine oxidase B, also known as MAOB, is a protein that in humans is encoded by the MAOB gene ... encoded by this gene belongs to the flavin monoamine oxidase family ...