What is methylation?

Methylation

In the chemical sciences, methylation denotes the addition of a methyl group to a substrate or the substitution of an atom or group by a methyl group. Methylation is a form of alkylation with, to be specific, a methyl group, rather than a larger carbon chain, replacing a hydrogen atom. These terms are commonly used in chemistry, biochemistry, soil science, and the biological sciences.

Read more about Methylation.

Some articles on methylation:

Small Nucleolar RNA Sno Z7/sno R77
... function in directing site-specific 2'-O-methylation of substrate RNAs ... snoZ7 RNA guides the methylation of 25S rRNA position A1372, whereas SnoR77Y guides the methylation of 18S rRNA at position U580 ...
Somatic Evolution In Cancer - Somatic Evolution in Progression - Somatic Evolution By Epigenetics
... alterations in tumors are the silencing or expression of genes by changes in the methylation of CG pairs of nucleotides in the promoter regions of ... These methylation patterns are copied to the new chromosomes when cells replicate their genomes and so methylation alterations are heritable and subject to ... Methylation changes are thought to occur more frequently than mutations in the DNA, and so may account for many of the changes during neoplastic ...
Methylated DNA Immunoprecipitation - Background
... DNA methylation, referring to the reversible methylation of the 5 position of cytosine by methyltransferases, is a major epigenetic modification in multicellular organisms ... The modification may also occur at other sites, but methylation at either of these sites can repress gene expression by either interfering with the binding of transcription factors or ... Disease condition studies have largely fueled the effort in understanding the role of DNA methylation ...
Methylated DNA Immunoprecipitation - Downstream Bioinformatics Analysis
... The DNA methylation level estimations can be confounded by varying densities of methylated CpG sites across the genome when observing data generated by MeDIP ... developed a tool to estimate absolute methylation levels from data generated by MeDIP by modeling the density of methylated CpG sites ... This tool is called Bayesian tool for methylation analysis (Batman) ...