What is ligase?

Ligase

In biochemistry, ligase (from the Latin verb ligāre — "to bind" or "to glue together") is an enzyme that can catalyze the joining of two large molecules by forming a new chemical bond, usually with accompanying hydrolysis of a small chemical group dependent to one of the larger molecules or the enzyme catalyzing the linking together of two compounds....e.g.: Enzymes which catalyze joining of C-O,C-S,C-N etc. .In general, a ligase catalyzes the following reaction:

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Some articles on ligase:

Lysine—t RNA(Pyl) Ligase
... In enzymology, a lysine-tRNAPyl ligase (EC 6.1.1.25) is an enzyme that catalyzes the chemical reaction ATP + L-lysine + tRNAPyl AMP + diphosphate + L-lysyl-tRNAPyl The 3 substrates of this enzyme are ATP, L-lysine ... This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds ... name of this enzyme class is L-lysinetRNAPyl ligase (AMP-forming) ...
Ligase Ribozyme - The L1 Ligase
... Michael Robertson and Andrew Ellington evolved a ligase ribozyme that performs the desired 5'-3' RNA assembly reaction, and called this the L1 ligase ...
Ligase Chain Reaction
... The ligase chain reaction (LCR) is a method of DNA amplification ... are ligated to form the actual one thus, LCR uses two enzymes a DNA polymerase and a DNA ligase ...
Ligase - Classification
... Ligases are classified as EC 6 in the EC number classification of enzymes ... Ligases can be further classified into six subclasses EC 6.1 includes ligases used to form carbon-oxygen bonds EC 6.2 includes ligases used to form carbon-sulfur ...
Anthranilate-Co A Ligase
... In enzymology, an anthranilate-CoA ligase (EC 6.2.1.32) is an enzyme that catalyzes the chemical reaction ATP + anthranilate + CoA AMP + diphosphate + anthranilyl-CoA The 3 substrates of this enzyme are ATP ... This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases ... The systematic name of this enzyme class is anthranilateCoA ligase (AMP-forming) ...