What is knockout mouse?

Knockout Mouse

A knockout mouse is a genetically engineered mouse in which researchers have inactivated, or "knocked out," an existing gene by replacing it or disrupting it with an artificial piece of DNA. The loss of gene activity often causes changes in a mouse's phenotype, which includes appearance, behavior and other observable physical and biochemical characteristics.

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Some articles on knockout mouse:

SEC16B - Model Organisms
... Sec16b knockout mouse phenotype Characteristic Phenotype Homozygote viability Normal Fertility Normal Body weight Normal Anxiety Normal Neurological ... A conditional knockout mouse line, called Sec16btm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis ...
SGOL2 - Function - Model Organisms
... Sgol2 knockout mouse phenotype Characteristic Phenotype Homozygote viability Normal Fertility Normal Body weight Normal Anxiety Normal Neurological assessment ... A conditional knockout mouse line, called Sgol2tm1a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput ... Using another genetically engineered mouse that lacks Sgol2 function, and siRNA experiments in oocytes, it has been shown that disruption of the mouse SGOL2 does not cause any alteration in sister ...
RUNX3 - Knockout Mouse
... Runx3 null mouse gastric mucosa exhibits hyperplasia due to stimulated proliferation and suppressed apoptosis in epithelial cells, and the cells are resistant to TGF-beta stimulation ...
Knockout Mouse - Limitations
... While knockout mouse technology represents a valuable research tool, some important limitations exist ... About 15 percent of gene knockouts are developmentally lethal, which means that the genetically altered embryos cannot grow into adult mice ... Knocking out a gene also may fail to produce an observable change in a mouse or may even produce different characteristics from those observed in humans in which the same gene is inactivated ...
ARID4A - Model Organisms
... Arid4a knockout mouse phenotype Characteristic Phenotype Homozygote viability Abnormal Recessive lethal study Abnormal Fertility Normal Body weight Abnormal Anxiety Normal Neurological assessment Normal Grip ... A conditional knockout mouse line, called Arid4atm1a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and ...

Famous quotes containing the word mouse:

    It is as when a migrating army of mice girdles a forest of pines. The chopper fells trees from the same motive that the mouse gnaws them,—to get his living. You tell me that he has a more interesting family than the mouse. That is as it happens.
    Henry David Thoreau (1817–1862)