Reverse genetics is an approach to discover the function of a gene by analyzing the phenotypic effects of specific gene sequences obtained by DNA sequencing. This investigative process proceeds in the opposite direction of so-called forward genetic screens of classical genetics. Simply put, while forward genetics seeks to find the genetic basis of a phenotype or trait, reverse genetics seeks to find what phenotypes arise as a result of particular genes.
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Some articles on reverse genetics:
... A technique called reverse genetics allows scientists to manipulate the genomes of influenza viruses and to transfer genes between viral strains ... By removing or modifying certain virulence genes, reverse genetics also can be used to convert highly pathogenic influenza viruses into vaccine candidates that are ...
... A molecular genetic approach is the creation of transgenic organisms that overexpress a normal gene of interest ...
... While forward genetic screens are productive, a more straightforward approach is to simply determine the phenotype that results from mutating a given gene ... This is called reverse genetics ... Alternative methods of reverse genetic research include the random induction of DNA deletions and subsequent selection for deletions in a gene of interest, as well as the application ...
Famous quotes containing the word reverse:
“During the late war [the American Revolution] I had an infallible rule for deciding what [Great Britain] would do on every occasion. It was, to consider what they ought to do, and to take the reverse of that as what they would assuredly do, and I can say with truth that I was never deceived.”
—Thomas Jefferson (17431826)