What are hippocampal sclerosis?

Hippocampal Sclerosis

Hippocampal sclerosis (HS) is a neuropathological condition with severe neuronal cell loss and gliosis in the hippocampus, specifically in the CA-1(Cornu Ammonis area 1) and subiculum of the hippocampus. It was first described in 1880 by Wilhelm Sommer. Hippocampal sclerosis is a frequent pathologic finding in community-based dementia. Hippocampal sclerosis can be dected with autopsy and MRI. Individuals with hippocampal sclerosis have similar initial symptoms and rates of dementia progression to those with Alzheimer's disease (AD) and therefore are frequently misclassfied as having Alzheimer's Disease. But clinical and pathologic findings suggest that hippocampal sclerosis has characteristics of a progressive disorder although the underlying cause remains elusive. A diagnosis of hippocampal sclerosis has a significant effect on the life of patients because of the notable mortality, morbidity and social impact related to epilepsy, as well as side effects associated with antiepileptic treatments.

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Some articles on hippocampal sclerosis:

Hippocampal Sclerosis - Symptoms - Temporal Lobe Epilepsy
... Ammon's horn (or Hippocampal) sclerosis (AHS) is the most common type of neuropathological damage seen in individuals with Temporal Lobe Epilepsy ... Although it is identified that hippocampal sclerosis is a distinctive feature of the pathology associated with Temporal Lobe Epilepsy, this disorder is not merely a consequence ... ongoing debate addresses the issue of whether hippocampal sclerosis is the cause or the consequence of chronic andpharmaceutically resistant seizure activity ...