Identifiers Symbols UBTF; NOR-90; UBF; UBF-1; UBF1 External IDs OMIM: 600673 MGI: 98512 HomoloGene: 7970 GeneCards: UBTF Gene

Gene Ontology
Molecular function DNA binding
protein binding
Cellular component nucleoplasm
Biological process blastocyst growth
regulation of transcription from RNA polymerase I promoter
transcription from RNA polymerase I promoter
transcription initiation from RNA polymerase I promoter
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
embryo implantation
gene expression
positive regulation of transcription from RNA polymerase I promoter
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7343 21429 Ensembl ENSG00000108312 ENSMUSG00000020923 UniProt P17480 A2AWT5 RefSeq (mRNA) NM_001076683 NM_001044383 RefSeq (protein) NP_001070151 NP_001037848 Location (UCSC) Chr 17:
42.28 – 42.3 Mb Chr 11:
102.3 – 102.32 Mb PubMed search

Nucleolar transcription factor 1 is a protein that in humans is encoded by the UBTF gene.

Upstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP (MIM 600075) and three TBP-associated factors or 'TAFs'). Two UBF polypeptides, of 94 and 97 kD, exist in the human (Bell et al., 1988). UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes (Jantzen et al., 1990).

Read more about UBTF:  Interactions

Other articles related to "ubtf":

UBTF - Interactions
... UBTF has been shown to interact with Casein kinase 2, alpha 1, TAF1C, Retinoblastoma protein and TAF1 ...