Ubiquitin is a small regulatory protein that has been found in almost all tissues (ubiquitously) of eukaryotic organisms. It directs proteins to compartments in the cell, including the proteasome which destroys and recycles proteins.
|A diagram of ubiquitin. The seven lysine sidechains are shown in orange.|
Ubiquitin can be attached to proteins and label them for destruction. This discovery won the Nobel Prize for chemistry in 2004.
Ubiquitin tags can also direct proteins to other locations in the cell, where they control other protein and cell mechanisms.
Read more about Ubiquitin: Identification, The Protein, Genes, Origins, Ubiquitination (ubiquitylation), Function and Variety of Ubiquitin Modifications, Ubiquitin-like Modifiers, Prokaryotic Ubiquitin-like Protein (Pup), Human Proteins Containing Ubiquitin Domain, Related Proteins, Prediction of Ubiquitination
Other articles related to "ubiquitin":
... SKP1 Gene EC number 18.104.22.168 Gene Ontology Molecular function • ubiquitin-protein ligase activity • protein binding Cellular component • nucleoplasm • cytosol • SCF ubiquitin ligase ... encodes a protein that is a member of the SCF ubiquitin ligase protein complex ... F, S-phase kinase-associated protein 2, and other regulatory proteins involved in ubiquitin dependent proteolysis ...
87858 GeneCards SUMO2 Gene Gene Ontology Molecular function • protein binding • ubiquitin protein ligase binding Cellular component • PML body Biological ... gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family ... It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system ...
55815 GeneCards CDC34 Gene EC number 22.214.171.124 Gene Ontology Molecular function • ubiquitin-protein ligase activity • protein binding • ATP binding Cellular component • nucleus ... numerous substrates (Sic1, Far1, Cln1, Cln2) for ubiquitin mediated degradation ... Ubiquitin-conjugating enzyme E2 R1 is a protein that in humans is encoded by the CDC34 gene ...
... LNX1 Gene EC number 126.96.36.199 Gene Ontology Molecular function • ubiquitin-protein ligase activity • protein binding • zinc ion binding • PDZ domain ...
... Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1 MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar ... Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature ...