Tumor Suppressors

Some articles on tumor suppressors, tumor suppressor:

Protein P16 - Function
... Both p16 and retinoblastoma (pRb) are important tumor suppressors that regulate the cell cycle ... In addition to protein p16, pRB there are many other important tumor suppressors that regulate the cell cycle and one of them is protein p53 ... G1 phase to S phase is blocked by protein p16, which is a potential tumor suppressor that acts to disrupt the complex cyclin D1 and CDK 4 or 6 ...
Carcinogenesis - Mechanisms - Tumor Suppressor Genes
... Tumor suppressor genes code for anti-proliferation signals and proteins that suppress mitosis and cell growth ... Generally, tumor suppressors are transcription factors that are activated by cellular stress or DNA damage ... as well as other signs, and will trigger enzymes and pathways that lead to the activation of tumor suppressor genes ...
Carcinogenesis - Mechanisms - Multiple Mutations
... For example, a mutation limited to one oncogene would be suppressed by normal mitosis control and tumor suppressor genes, first hypothesised by the Knudson hypothesis ... A mutation to only one tumor suppressor gene would not cause cancer either, due to the presence of many "backup" genes that duplicate its functions ... It is only when enough proto-oncogenes have mutated into oncogenes, and enough tumor suppressor genes deactivated or damaged, that the signals for cell growth ...