Tumor Suppressor Genes

Tumor Suppressor Genes

A tumor suppressor gene, or anti-oncogene, is a gene that protects a cell from one step on the path to cancer. When this gene is mutated to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with other genetic changes.

Read more about Tumor Suppressor Genes:  Two-hit Hypothesis, Functions, Examples, See Also

Other articles related to "tumor suppressor, genes, gene, tumor suppressor genes, suppressor, tumor suppressors, tumor suppressor gene":

La Jolla Institute For Allergy And Immunology - Cancer Research - Tumor Suppressor
... play a role in allergy onset, instead have discovered its previously unknown role as a tumor suppressor that may be important in myeloproliferative diseases and some types of lymphoma and leukemia ... we found was a completely different function that no one knew it had - as a tumor suppressor," said the La Jolla Institute's Toshiaki Kawakami, M.D ...
List Of Me SH Codes (G14) - MeSH G14 --- Genetic Structures - MeSH G14.340 --- Genome - MeSH G14.340.024 --- Genome Components
... regions MeSH G14.340.024.340 --- genes MeSH G14.340.024.340.077 --- alleles MeSH G14.340.024.340.137 --- gene components MeSH G14.340.024.340.137.190 ...
Tumor Suppressor Genes - See Also
... Metastasis suppressor Adenomatosis polyposis coli Oncogene Cancer DNA repair Signal transduction Von Hippel Lindau Binding protein 1 BRCA1 p53 ...
Carcinogenesis - Mechanisms - Tumor Suppressor Genes
... Tumor suppressor genes code for anti-proliferation signals and proteins that suppress mitosis and cell growth ... Generally, tumor suppressors are transcription factors that are activated by cellular stress or DNA damage ... as other signs, and will trigger enzymes and pathways that lead to the activation of tumor suppressor genes ...
Carcinogenesis - Mechanisms - Multiple Mutations
... In general, mutations in both types of genes are required for cancer to occur ... For example, a mutation limited to one oncogene would be suppressed by normal mitosis control and tumor suppressor genes, first hypothesised by the Knudson hypothesis ... A mutation to only one tumor suppressor gene would not cause cancer either, due to the presence of many "backup" genes that duplicate its functions ...

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