Tryptophan Repressor

Tryptophan repressor (or trp repressor) is a transcription factor involved in controlling amino acid metabolism. It has been best studied in Escherichia coli, where it is a dimeric protein that regulates transcription of the 5 genes in the tryptophan operon. When the amino acid tryptophan is plentiful in the cell, it binds to the protein, which causes a conformational change in the protein. The repressor complex then binds to its operator sequence in the genes it regulates, shutting off the genes.

One of the genes regulated by trp repressor, trpR, codes for the tryptophan repressor protein. This is a form of feedback regulation.

The (tryptophan) repressor is a 25 kD protein homodimer which regulates transcription of the tryptophan biosynthetic pathway in bacteria. There are 5 operons which are regulated by trpR: the trpEDCBA, trpR, AroH, AroL, and mtr operons.

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Other articles related to "tryptophan repressor, tryptophan, repressor":

Tryptophan Repressor - Mechanism
... When the amino acid tryptophan is in plentiful supply in the cell, trpR binds 2 molecules of tryptophan, which alters its structure and dynamics so that it ... suppressing the products of the gene - proteins which make more tryptophan ... When the cellular levels of tryptophan decline, the tryptophan molecules on the repressor fall off, allowing the repressor to return to its inactive form ...
Amino Acid Synthesis - Amino Acid Biosynthesis Is Regulated By Feedback Inhibition - Additional Regulation Based On Amino Acid Families - Erythrose 4-phosphate and Phosphoenolpyruvate Family
... Phenylalanine, tyrosine, and tryptophan are known as the aromatic amino acids ... Each one of these has its synthesis regulated from tyrosine, phenylalanine, and tryptophan, respectively ... the final end product, either tyrosine, phenylalanine, or tryptophan ...