Transthyretin

Transthyretin

Identifiers Symbols TTR; CTS; CTS1; HsT2651; PALB; TBPA External IDs OMIM: 176300 MGI: 98865 HomoloGene: 317 ChEMBL: 3194 GeneCards: TTR Gene

Gene Ontology
Molecular function hormone activity
protein binding
hormone binding
Cellular component extracellular region
extracellular space
cytoplasm
Biological process transport
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7276 22139 Ensembl ENSG00000118271 ENSMUSG00000061808 UniProt P02766 P07309 RefSeq (mRNA) NM_000371.3 NM_013697.5 RefSeq (protein) NP_000362.1 NP_038725.1 Location (UCSC) Chr 18:
29.17 – 29.18 Mb Chr 18:
20.67 – 20.67 Mb PubMed search

Transthyretin (TTR) is a serum and cerebrospinal fluid carrier of the thyroid hormone thyroxine (T4) and retinol binding protein bound to retinol. This is how transthyretin gained its name, transports thyroxine and retinol. The liver secretes transthyretin into the blood, and the choroid plexus secretes TTR into the cerebrospinal fluid.

TTR was originally called prealbumin (or Thyroxine-binding prealbumin) because it ran faster than albumin on electrophoresis gels.

Read more about Transthyretin:  Binding Affinities, Structure, Role in Disease, Nutritional Assessment, Interactions

Other articles related to "transthyretin":

Carpal Tunnel Syndrome - Causes
... Carpal tunnel syndrome often is a symptom of transthyretin amyloidosis-associated polyneuropathy and prior carpal tunnel syndrome surgery is very common in individuals who later ...
Jeffery W. Kelly
... Alzheimer's disease, Parkinson's Disease, and the familial gelsolin and transthyretin-based amyloidoses–publishing over 250 peer-reviewed papers in this area to date ... that diflunisal kinetically stabilizes transthyretin, enabling a placebo controlled clinical trial with it to ameliorate familial amyloid polyneuropathy–the results of which will be announced in ... is credited with demonstrating that transthyretin conformational changes alone are sufficient for amyloidogenesis, discovering the first example of functional amyloid in ...
Transthyretin - Interactions
... Transthyretin has been shown to interact with Perlecan. ...
Transthyretin-related Hereditary Amyloidosis
... Familial amyloid polyneuropathy (FAP), also called transthyretin-related hereditary amyloidosis, transthyretin amyloidosis or Corino de Andrade's disease, is an ...
Bleach And Recycle - Retinoid Transport To The Retina
... pathway, it is bound to Retinol Binding Protein (RBP) and Transthyretin, which prevents its filtration in the glomeruli ... It is via this RBP-Transthyretin pathway that the retina receives most of its retinoids ... As in transport via the RBP-Transthyretin pathway, retinoids must always be bound to chaperone molecules, for several reasons ...