Tolcapone (tradename Tasmar) is a selective, potent and reversible nitro catechol type inhibitor of enzyme catechol-O-methyl transferase (COMT).

Read more about Tolcapone:  Uses, Chemistry, History, Synthesis, Pharmacodynamics, Pharmacokinetics, Treatment, Adverse Effects, See Also

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COMT Inhibitor
... Pharmaceutical examples include entacapone, tolcapone, and nitecapone ... is only peripherally active, whereas both tolcapone and nitecapone are active in both the periphery and central nervous system ... Tolcapone and nitecapone are known to be hepatotoxic, whereas entacapone is not ...