Taxane 10beta-hydroxylase

In enzymology, a taxane 10beta-hydroxylase (EC 1.14.13.76) is an enzyme that catalyzes the chemical reaction

taxa-4(20),11-dien-5alpha-yl acetate + NADPH + H+ + O2 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP+ + H2O

The 4 substrates of this enzyme are taxa-4(20),11-dien-5alpha-yl acetate, NADPH, H+, and O2, whereas its 3 products are 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate, NADP+, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is taxa-4(20),11-dien-5alpha-yl acetate,NADPH:oxygen oxidoreductase (10beta-hydroxylating). This enzyme participates in diterpenoid biosynthesis.