Target Protein

Target Protein

Target proteins are functional biomolecules that are addressed and controlled by biologically active compounds. They are used in the processes of transduction, transformation and conjugation. The identification of target proteins, the investigation of signal transduction processes and the understanding of their interaction with ligands are key elements of modern biomedical research. Since the interaction with target proteins is the molecular origin of most drugs, their particular importance for molecular biology, molecular pharmacy and pharmaceutical sciences is obvious. Target proteins control the action and the kinetic behavior of drugs within the organism. The elucidation of structure, conformational signaling and catalytic properties of particular target proteins facilitates a rational design of drugs and biotechnological processes. Known as biologicals, target proteins can also be drugs by themselves when their modification and formulation is emphasized within the pharmaceutical sciences. Finally, target protein - inducer interactions can be exploited for biomolecular transcription regulating systems in order to control for example gene therapeutic approaches.

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Other articles related to "protein, target protein, proteins, target":

Vector (molecular Biology) - Features
... Vector contains a sequence for a specific epitope that is incorporated into the expressed protein ... Allows for antibody identification of cells expressing the target protein ... Other commonly used reporters include green fluorescent protein and luciferase ...
Reverse Phase Protein Lysate Microarray
... Reverse phase protein array (RPPA) is a protein array designed as a micro- or nano-scaled dot-blot platform that allows measurement of protein expression levels in a large number of ... that is then incubated with a single specific antibody to detect expression of the target protein across many samples ... provide direct quantifiable information concerning post translationally modified proteins that are not accessible with other high-throughput techniques ...
Inteins in Biotechnology
... Inteins are very efficient at protein splicing, and they have accordingly found an important role in biotechnology ... Inteins have been engineered for particular applications such as protein semisynthesis and the selective labeling of protein segments, which is useful for NMR ... of intein excision may be a useful tool for drug development the protein that contains the intein will not carry out its normal function if the intein does not excise ...
Methods For Epitope Mapping
... Epitope mapping of complex target antigens, such as integral membrane proteins or multi-subunit proteins, is often challenging because of the difficulty in ... There are several methods available for mapping antibody epitopes on target antigens The gold standard approach is X-ray co-crystallography, which allows direct visualization of the interaction between the antigen ... However, this approach is technically challenging, requires large amounts of purified protein, and can be time-consuming and expensive ...

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