T-cell Leukemia

T-cell leukemia describes several different types of lymphoid leukemia which affect T cells.

Types include:

  • Large granular lymphocytic leukemia
  • Adult T-cell leukemia/lymphoma
  • T-cell prolymphocytic leukemia

In practice, it can be hard to distinguish T-cell leukemia from T-cell lymphoma, and they are often grouped together.

This article includes a list of related items that share the same name (or similar names).
If an internal link incorrectly led you here, you may wish to change the link to point directly to the intended article.
Hematological malignancy/leukemia histology (ICD-O 9590–9989, C81–C96, 200–208)
Lymphoid/Lymphoproliferative, Lymphomas/Lymphoid leukemias (9590–9739, 9800–9839)
B cell
(lymphoma,
leukemia)
(most CD19
  • CD20)
By development/
marker
TdT+
  • ALL (Precursor B acute lymphoblastic leukemia/lymphoma)
CD5+
  • naive B cell (CLL/SLL)
mantle zone (Mantle cell)
CD22+
  • Prolymphocytic
  • CD11c+ (Hairy cell leukemia)
CD79a+
  • germinal center/follicular B cell (Follicular
  • Burkitt's
  • GCB DLBCL
  • Primary cutaneous follicular lymphoma)
marginal zone/marginal-zone B cell (Splenic marginal zone
  • MALT
  • Nodal marginal zone
  • Primary cutaneous marginal zone lymphoma)
RS (CD15+, CD30+)
  • Classic Hodgkin's lymphoma (Nodular sclerosis)
  • CD20+ (Nodular lymphocyte predominant Hodgkin's lymphoma)
PCDs/PP
(CD38+/CD138+)
  • see immunoproliferative immunoglobulin disorders
By infection
  • KSHV (Primary effusion)
  • EBV (Lymphomatoid granulomatosis
  • Post-transplant lymphoproliferative disorder)
  • HIV (AIDS-related lymphoma)
  • Helicobacter pylori (MALT lymphoma)
Cutaneous
  • Diffuse large B-cell lymphoma
  • Intravascular large B-cell lymphoma
  • Primary cutaneous marginal zone lymphoma
  • Primary cutaneous immunocytoma
  • Plasmacytoma
  • Plasmacytosis
  • Primary cutaneous follicular lymphoma
T/NK
T cell
(lymphoma,
leukemia)
(most CD3
  • CD4
  • CD8)
By development/
marker
  • TdT+: ALL (Precursor T acute lymphoblastic leukemia/lymphoma)
  • prolymphocyte (Prolymphocytic)
  • CD30+ (Anaplastic large-cell lymphoma
  • Lymphomatoid papulosis type A)
Cutaneous
MF+variants
  • indolent: Mycosis fungoides
  • Pagetoid reticulosis
  • Granulomatous slack skin

aggressive: Sézary's disease

  • Adult T-cell leukemia/lymphoma
Non-MF
  • CD30-: Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma
  • Pleomorphic T-cell lymphoma
  • Lymphomatoid papulosis type B

CD30+: CD30+ cutaneous T-cell lymphoma

Other peripheral
  • Hepatosplenic
  • Angioimmunoblastic
  • Enteropathy-associated T-cell lymphoma
  • Peripheral T-cell lymphoma-Not-Otherwise-Specified (Lennert lymphoma)
  • Subcutaneous T-cell lymphoma
By infection
  • HTLV-1 (Adult T-cell leukemia/lymphoma)
NK cell/
(most CD56)
T or NK
  • EBV (Extranodal NK-T-cell lymphoma/Angiocentric lymphoma)
  • Large granular lymphocytic leukemia
Lymphoid+myeloid
  • Acute biphenotypic leukaemia
Lymphocytosis
  • Lymphoproliferative disorders (X-linked lymphoproliferative disease
  • Autoimmune lymphoproliferative syndrome)
  • Leukemoid reaction
  • Diffuse infiltrative lymphocytosis syndrome
Cutaneous lymphoid hyperplasia
  • Cutaneous lymphoid hyperplasia with bandlike and perivascular patterns
  • Cutaneous lymphoid hyperplasia with nodular pattern
  • Jessner lymphocytic infiltrate of the skin

M: LMC

cell/phys/auag/auab/comp, igrc

imdf/ipig/hyps/tumr

proc, drug (L3/4)