Subgranular Zone - Structure - Endothelial Cells and Blood Vessels

Endothelial Cells and Blood Vessels

Endothelial cells, which line the blood vessels in the SGZ, are a critical component in the regulation of stem cell self-renewal and neurogenesis. These cells, which reside in close proximity to clusters of proliferating neurogenic cells, provide attachment points for neurogenic cells and release diffusible signals such as vascular endothelial growth factor (VEGF) that help induce both angiogenesis and neurogenesis. In fact, studies have shown that neurogenesis and angiogenesis share several common signaling pathways, implying that neurogenic cells and endothelial cells in the SGZ have a reciprocal effect on one another. Blood vessels carry hormones and other molecules that act on the cells in the SGZ to regulate neurogenesis and angiogenesis.

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