SREBP Cleavage Activating Protein
Sterol regulatory element-binding protein cleavage-activating protein, also known as SREBP cleavage-activating protein or SCAP is a protein that in humans is encoded by the SCAP gene.
SCAP contains a sterol sensing domain (SSD) and seven WD domains. In cholesterol-depleted cells, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi apparatus. The SREBPs are then proteolytically cleaved and stimulate sterol biosynthesis.
Other articles related to "srebp cleavage activating protein":
... Scap has 8 transmembrane domains and both the N-terminal and C-terminal face the cytoplasm ... Also, it binds SREBP by a series of consecutive WD repeats on its C-terminus ...
Famous quotes containing the words protein, activating and/or cleavage:
“Firm-style bean curd insoles cushion feet, absorb perspiration and provide more protein than meat or fish innersoles of twice the weight. Tofu compresses with use, becoming more pungent and flavorful. May be removed when not in use to dry or marinate. Innersoles are ready to eat after 1,200 miles of wear. Each pair provides adult protein requirement for 2 meals. Insoles are sized large to allow for snacks. Recipe booklet included.”
—Alfred Gingold, U.S. humorist. Items From Our Catalogue, Tofu Innersoles, Avon Books (1982)
“it is best then that the buried word remain buried for we were intended to appreciate only its fruits and not the secret principle activating them to know this would be to know too much. Meanwhile it is possible to know just enough, and this is all we were supposed to know, toward which we have been straining all our lives.”
—John Ashbery (b. 1927)
“Jesus abolished the very concept of guiltMhe denied any cleavage between God and man. He lived this unity of God and man as his glad tidings ... and not as a prerogative!”
—Friedrich Nietzsche (18441900)