SREBP Cleavage Activating Protein

SREBP Cleavage Activating Protein

Sterol regulatory element-binding protein cleavage-activating protein, also known as SREBP cleavage-activating protein or SCAP is a protein that in humans is encoded by the SCAP gene.

SCAP contains a sterol sensing domain (SSD) and seven WD domains. In cholesterol-depleted cells, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi apparatus. The SREBPs are then proteolytically cleaved and stimulate sterol biosynthesis.

Read more about SREBP Cleavage Activating ProteinFunction, Structure

Other articles related to "srebp cleavage activating protein":

SREBP Cleavage Activating Protein - Structure
... Scap has 8 transmembrane domains and both the N-terminal and C-terminal face the cytoplasm ... Also, it binds SREBP by a series of consecutive WD repeats on its C-terminus ...

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