Squalene

Squalene is a natural organic compound originally obtained for commercial purposes primarily from shark liver oil, though plant sources (primarily vegetable oils) are used as well, including amaranth seed, rice bran, wheat germ, and olives. All plants and animals produce squalene, including humans. Squalene has been proposed to be an important part of the Mediterranean diet as it may be a chemopreventative substance that protects people from cancer. It is also found in the stomach oil of birds in the order Procellariiformes.

Squalene is a hydrocarbon and a triterpene, and is a natural and vital part of the synthesis of cholesterol, steroid hormones, and vitamin D in the human body. Squalene is used in cosmetics, and more recently as an immunologic adjuvant in vaccines.

Read more about Squalene:  Role in Steroid Synthesis, Biosynthesis, Interactive Pathway Map, Shark Squalene, Derivative Used As A Skin Moisturizer in Cosmetics, Use As An Adjuvant in Vaccines, Health Controversy

Other articles related to "squalene":

Lanosterol - Biosynthesis
... pyrophosphate condense with reduction by NADPH to form squalene squalene synthase Squalene is oxidized to 2,3-oxidosqualene (squalene epoxide) squalene monooxygenase 2,3-Oxidosqualene ...
Squalene - Health Controversy
... There have been attempts to link squalene to Gulf War Syndrome mainly due to the idea that squalene might have been present in an anthrax vaccine given to some ... patients are significantly more likely to have antibodies to squalene (95 percent) than asymptomatic Gulf War veterans (0 percent p ...
Farnesyl-diphosphate Farnesyltransferase - Clinical Significance
... Inhibition of squalene synthase, e.g ... being investigated for clinical use.) Other squalene synthase inhibitors include Zaragozic acid, and RPR 107393 ... Squalene synthase homolog inhibition in Staphylococcus aureus is currently being investigated as a virulence factor-based antibacterial therapy ...
Squalene Monooxygenase - Mechanism
... Squalene monooxygenase is a flavoprotein monooxygenase ... Squalene monooxygenase differs from other flavin monooxygenases in that the oxygen is inserted as an epoxide rather than as a hydroxyl group ... Squalene monooxygenase contains a loosely bound FAD flavin and obtains electrons from NADPH-cytochrome P450 reductase, rather than binding the nicotinamide cofactor ...
Squalene Monooxygenase
... Squalene monooxygenase is an enzyme that uses NADPH and molecular oxygen to oxidize squalene to 2,3-oxidosqualene (squalene epoxide) ... Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway ... In humans, squalene epoxidase is encoded by the SQLE gene ...