Sonic Hedgehog

Sonic Hedgehog

Identifiers Symbols SHH; HHG1; HLP3; HPE3; MCOPCB5; SMMCI; TPT; TPTPS External IDs OMIM: 600725 MGI: 98297 HomoloGene: 30961 ChEMBL: 5602 GeneCards: SHH Gene

Gene Ontology
Molecular function glycoprotein binding
signal transducer activity
patched binding
calcium ion binding
protein binding
glycosaminoglycan binding
peptidase activity
zinc ion binding
morphogen activity
laminin-1 binding
Cellular component extracellular space
nucleus
endoplasmic reticulum
Golgi apparatus
plasma membrane
cell surface
transport vesicle
extracellular matrix
membrane raft
Biological process negative regulation of transcription from RNA polymerase II promoter
patterning of blood vessels
vasculogenesis
metanephros development
branching involved in ureteric bud morphogenesis
response to hypoxia
cell fate specification
neural crest cell migration
neural tube formation
heart looping
positive regulation of neuroblast proliferation
osteoblast development
lymphoid progenitor cell differentiation
determination of left/right asymmetry in lateral mesoderm
proteolysis
endocytosis
apoptotic process
smoothened signaling pathway
positive regulation of hh target transcription factor activity
cell-cell signaling
pattern specification process
ectoderm development
neuroblast proliferation
axon guidance
central nervous system development
ventral midline development
hindgut morphogenesis
digestive tract mesoderm development
heart development
blood coagulation
androgen metabolic process
positive regulation of cell proliferation
embryo development
embryonic pattern specification
anterior/posterior pattern specification
dorsal/ventral pattern formation
response to organic nitrogen
oligodendrocyte development
positive regulation of skeletal muscle cell proliferation
myotube differentiation
intein-mediated protein splicing
ventral spinal cord interneuron specification
dorsal/ventral neural tube patterning
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
telencephalon regionalization
establishment of cell polarity
regulation of proteolysis
positive regulation of Wnt receptor signaling pathway
lung development
embryonic limb morphogenesis
negative regulation of cell migration
male genitalia development
prostate gland development
regulation of epithelial cell differentiation
thyroid gland development
forebrain development
midbrain development
hindbrain development
pancreas development
hair follicle morphogenesis
response to estradiol stimulus
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
response to retinoic acid
regulation of protein localization
T cell differentiation in thymus
positive regulation of T cell differentiation in thymus
positive regulation of immature T cell proliferation in thymus
negative regulation of transcription elongation from RNA polymerase II promoter
protein localization to nucleus
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
regulation of cell proliferation
negative regulation of T cell proliferation
positive regulation of protein import into nucleus
odontogenesis of dentin-containing tooth
embryonic digit morphogenesis
camera-type eye development
negative regulation of apoptotic process
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
tongue morphogenesis
skin development
positive thymic T cell selection
negative thymic T cell selection
intermediate filament organization
myoblast differentiation
response to ethanol
negative regulation of cell differentiation
positive regulation of smoothened signaling pathway
positive regulation of transcription, DNA-dependent
positive regulation of transcription from RNA polymerase II promoter
positive regulation of photoreceptor cell differentiation
positive regulation of alpha-beta T cell differentiation
negative regulation of alpha-beta T cell differentiation
cell development
thymus development
embryonic digestive tract morphogenesis
embryonic foregut morphogenesis
positive regulation of skeletal muscle tissue development
organ formation
neuron fate commitment
response to axon injury
embryonic skeletal system development
positive regulation of oligodendrocyte differentiation
branching morphogenesis of a tube
male genitalia morphogenesis
inner ear development
formation of anatomical boundary
stem cell development
positive regulation of striated muscle cell differentiation
positive regulation of cell division
Bergmann glial cell differentiation
palate development
canonical Wnt receptor signaling pathway
limb bud formation
positive regulation of penile erection
lung epithelium development
trachea morphogenesis
branching involved in salivary gland morphogenesis
bud outgrowth involved in lung branching
right lung development
left lung development
lung lobe morphogenesis
lung-associated mesenchyme development
primary prostatic bud elongation
prostate epithelial cord elongation
salivary gland cavitation
epithelial cell proliferation involved in salivary gland morphogenesis
regulation of prostatic bud formation
epithelial-mesenchymal signaling involved in prostate gland development
positive regulation of epithelial cell proliferation involved in prostate gland development
regulation of mesenchymal cell proliferation involved in prostate gland development
mesenchymal smoothened signaling pathway involved in prostate gland development
artery development
mesenchymal cell proliferation involved in lung development
somite development
positive regulation of sclerotome development
positive regulation of oligodendrocyte progenitor proliferation
cellular response to lithium ion
renal system development
metanephric mesenchymal cell proliferation involved in metanephros development
multicellular structure septum development
negative regulation of canonical Wnt receptor signaling pathway
negative regulation of cholesterol efflux
regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
negative regulation of ureter smooth muscle cell differentiation
positive regulation of ureter smooth muscle cell differentiation
negative regulation of kidney smooth muscle cell differentiation
positive regulation of kidney smooth muscle cell differentiation
positive regulation of mesenchymal cell proliferation involved in ureter development
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 6469 20423 Ensembl ENSG00000164690 ENSMUSG00000002633 UniProt Q15465 Q62226 RefSeq (mRNA) NM_000193.2 NM_009170.3 RefSeq (protein) NP_000184.1 NP_033196.1 Location (UCSC) Chr 7:
155.59 – 155.6 Mb Chr 5:
28.46 – 28.47 Mb PubMed search

Sonic hedgehog homolog (SHH) is one of three proteins in the mammalian signaling pathway family called hedgehog, the others being desert hedgehog (DHH) and Indian hedgehog (IHH). SHH is the best studied ligand of the hedgehog signaling pathway. It plays a key role in regulating vertebrate organogenesis, such as in the growth of digits on limbs and organization of the brain. Sonic hedgehog is the best established example of a morphogen as defined by Lewis Wolpert's French flag model—a molecule that diffuses to form a concentration gradient and has different effects on the cells of the developing embryo depending on its concentration. SHH remains important in the adult. It controls cell division of adult stem cells and has been implicated in development of some cancers.

Read more about Sonic Hedgehog:  Discovery, Function, Processing, Robotnikinin, Criticism of The Name

Other articles related to "sonic hedgehog, hedgehog, sonic":

Sonic Hedgehog - Criticism of The Name
... or disability are told that they or their child have a mutation in a gene such as Sonic hedgehog." ...
Cancer Stem Cell - Pathways - Sonic Hedgehog and Wnt
... Both Sonic hedgehog (SHH) and Wnt pathways are commonly hyperactivated in tumors and are required to sustain tumor growth ... For instance, in colon cancer hedgehog signalling appears to antagonise Wnt ... Sonic hedgehog blockers are available, such as cyclopamine ...
Dr. R - Cultural Impact
... A potential macrocycle inhibitor of Sonic hedgehog discovered by a Harvard University research team was named "Robotnikinin" after the Dr ... The researchers felt that after Sonic hedgehog was named after the Sega video game character, they should "adhere to the convention" in naming the inhibiting compound after the ... a song called "So Sexy Robotnik" based on the boss theme from Sonic the Hedgehog 2 and features snips from various other level tunes from the same game ...
LMBR1
... disruption of this genic region can alter sonic hedgehog expression and affect limb patterning, but it is not known if this gene functions directly in limb development ... polydactyly, which likely result from altered sonic hedgehog expression ...
Hedgehog Signaling Pathway - Vertebrates - Role
... Members of the hedgehog family play key roles in a wide variety of developmental processes ... One of the best studied examples is the action of Sonic hedgehog during development of the vertebrate limb ... This diffusible factor was later shown to be Sonic hedgehog ...