Smoothened

Smoothened is a G protein-coupled receptor protein encoded by the SMO gene of the hedgehog pathway conserved from flies to humans. It is the molecular target of the teratogen cyclopamine.

Cellular localization plays an essential role in the function of SMO. Stimulation of the patched receptor by the sonic hedgehog ligand leads to translocation of SMO to the primary cilium. Furthermore, SMO that is mutated in the domain required for ciliary localisation cannot contribute to pathway activation. SMO has also been shown to bind the kinesin motor protein Costal-2 and play a role in the localization of the Ci (Cubitus interruptus transcription factor) complex.

SMO can function as an oncogene. Activating SMO mutations can lead to unregulated activation of the hedgehog pathway and cancer.

Read more about Smoothened:  See Also

Other articles related to "smoothened":

Hedgehog Signaling Pathway - Evolution
... families are very large and function without the need for a Smoothened homolog, suggesting a distinct pattern of selection for cholesterol modification and sensing mechanisms in coelomate and pseudo-coelomate ... of WNT receptors have some sequence similarity to Smoothened ... been difficult to link to the function Smoothened ...
Smoothened - See Also
... Frizzled Vismodegib, a smoothened receptor inhibitor being investigated for the treatment of cancer ...
GPR88
2 7. 8)) GPRC6A GPR (156 158 179) RAIG (1 3. 4) Class F Frizzled / Smoothened Frizzled Frizzled (1 9. 10) Smoothened Smoothened B trdu iter (nrpl/g ...
Jervine - Mechanism of Action
... via its interaction with the 7 pass trans membrane protein smoothened ... Jervine binds with and inhibits smoothened, which is an integral part of the hedgehog signaling pathways ... With smoothened inhibited, the GLI1 transcription cannot be activated and hedgehog target genes cannot be transcribed ...
Patched - Role in Presence and Absence of Hedgehog Signaling
... Patched, Patched somehow inhibits the activity of Smoothened, a G protein-coupled receptor, most of which is stored in membrane bound vesicles internally ... Smoothened must be present on the cell membrane in order for the Hedgehog signaling pathway to be activated ... with the accumulation of the Patched protein limiting signaling through the Smoothened protein ...