# SMC1A - Function

Function

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.

### Other articles related to "functions, function":

Formal Definitions - Lebesgue Integral
... For instance, a sequence of functions can frequently be constructed that approximate, in a suitable sense, the solution to a problem ... Then the integral of the solution function should be the limit of the integrals of the approximations ... However, many functions that can be obtained as limits are not Riemann integrable, and so such limit theorems do not hold with the Riemann integral ...
Integral - Fundamental Theorem of Calculus
... statement that differentiation and integration are inverse operations if a continuous function is first integrated and then differentiated, the original function is retrieved ... theorem of calculus, allows one to compute integrals by using an antiderivative of the function to be integrated ...
Integral - Extensions - Multiple Integration
... In general, an integral over a set E of a function f is written Here x need not be a real number, but can be another suitable quantity, for instance, a vector ... Just as the definite integral of a positive function of one variable represents the area of the region between the graph of the function and the x-axis, the double integral of a ... volume can be obtained via the triple integral — the integral of a function in three variables — of the constant function f(x, y, z) = 1 over the above mentioned region between the ...

### Famous quotes containing the word function:

The function of the actor is to make the audience imagine for the moment that real things are happening to real people.
George Bernard Shaw (1856–1950)

The fact remains that the human being in early childhood learns to consider one or the other aspect of bodily function as evil, shameful, or unsafe. There is not a culture which does not use a combination of these devils to develop, by way of counterpoint, its own style of faith, pride, certainty, and initiative.
Erik H. Erikson (1904–1994)

The mother’s and father’s attitudes toward the child correspond to the child’s own needs.... Mother has the function of making him secure in life, father has the function of teaching him, guiding him to cope with those problems with which the particular society the child has been born into confronts him.
Erich Fromm (1900–1980)