Identifiers Symbols SIN3A; DKFZp434K2235; FLJ90319; KIAA0700 External IDs OMIM: 607776 MGI: 107157 HomoloGene: 32124 GeneCards: SIN3A Gene

Gene Ontology
Molecular function RNA polymerase II activating transcription factor binding
RNA polymerase II repressing transcription factor binding
RNA polymerase II transcription corepressor activity
DNA binding
chromatin binding
sequence-specific DNA binding transcription factor activity
transcription corepressor activity
protein binding
protein complex binding
protein deacetylase activity
Cellular component kinetochore
transcription factor complex
Sin3 complex
transcriptional repressor complex
Biological process negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
activation of innate immune response
positive regulation of defense response to virus by host
DNA replication
protein deacetylation
blood coagulation
response to organic nitrogen
positive regulation of chromatin silencing
cellular protein localization
negative regulation of apoptotic process
regulation of transcription from RNA polymerase II promoter in response to oxidative stress
cellular lipid metabolic process
small molecule metabolic process
negative regulation of transcription, DNA-dependent
positive regulation of transcription from RNA polymerase II promoter
interphase of mitotic cell cycle
response to methylglyoxal
cellular response to glucose stimulus
negative regulation of protein localization to nucleus
negative regulation of histone H3-K27 acetylation
negative regulation of transcription regulatory region DNA binding
Sources: Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25942 20466 Ensembl ENSG00000169375 ENSMUSG00000042557 UniProt Q96ST3 Q60520 RefSeq (mRNA) NM_001145357 NM_001110350 RefSeq (protein) NP_001138829 NP_001103820 Location (UCSC) Chr 15:
75.66 – 75.75 Mb Chr 9:
57.07 – 57.13 Mb PubMed search

Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene.

The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.

Read more about SIN3A:  Interactions, See Also