Silver Acetate - Reactions - Direct ortho-arylation

Direct ortho-arylation

Silver acetate is a useful reagent for direct ortho-arylation (to install two adjacent substituents on an aromatic ring) for of benzylamines and N-methylbenzylamines. The reaction is palladium-catalized and requires a slight excess of silver acetate. This reaction is shorter than previous ortho-arylation methods.

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