Signal Transducing Adaptor Molecule

Signal Transducing Adaptor Molecule

Identifiers Symbols STAM; STAM-1; STAM1 External IDs OMIM: 601899 MGI: 1329014 HomoloGene: 37788 GeneCards: STAM Gene

Gene Ontology
Molecular function SH3/SH2 adaptor activity
protein binding
Cellular component cytosol
early endosome membrane
Biological process intracellular protein transport
signal transduction
epidermal growth factor receptor signaling pathway
cellular membrane organization
endosomal transport
negative regulation of epidermal growth factor receptor signaling pathway
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 8027 20844 Ensembl ENSG00000136738 ENSMUSG00000026718 UniProt Q92783 P70297 RefSeq (mRNA) NM_003473 NM_011484 RefSeq (protein) NP_003464 NP_035614 Location (UCSC) Chr 10:
17.69 – 17.76 Mb Chr 2:
14.07 – 14.15 Mb PubMed search

Signal transducing adapter molecule 1 is a protein that in humans is encoded by the STAM gene.

This gene was identified by the rapid tyrosine-phosphorylation of its product in response to cytokine stimulation. The encoded protein contains an SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). This protein associates with JAK3 and JAK2 kinases via its ITAM region, and is phosphorylated by the JAK kinases upon cytokine stimulation, which suggests the function of this protein is as an adaptor molecule involved in the downstream signaling of cytokine receptors. HGS/HRS (hepatocyte growth factor-regulated tyrosine kinase substrate) has been found to bind and counteract the function of this protein.

Read more about Signal Transducing Adaptor Molecule:  Interactions

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Signal Transducing Adaptor Molecule - Interactions
... Signal transducing adaptor molecule has been shown to interact with STAMBP, HGS, TIMM8A and Janus kinase 2 ...

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