Signal Transducing Adaptor Molecule
|Molecular function||• SH3/SH2 adaptor activity
• protein binding
|Cellular component||• cytosol
• early endosome membrane
|Biological process||• intracellular protein transport
• signal transduction
• epidermal growth factor receptor signaling pathway
• cellular membrane organization
• endosomal transport
• negative regulation of epidermal growth factor receptor signaling pathway
|Sources: Amigo / QuickGO|
17.69 – 17.76 Mb
14.07 – 14.15 Mb
Signal transducing adapter molecule 1 is a protein that in humans is encoded by the STAM gene.
This gene was identified by the rapid tyrosine-phosphorylation of its product in response to cytokine stimulation. The encoded protein contains an SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). This protein associates with JAK3 and JAK2 kinases via its ITAM region, and is phosphorylated by the JAK kinases upon cytokine stimulation, which suggests the function of this protein is as an adaptor molecule involved in the downstream signaling of cytokine receptors. HGS/HRS (hepatocyte growth factor-regulated tyrosine kinase substrate) has been found to bind and counteract the function of this protein.
Read more about Signal Transducing Adaptor Molecule: Interactions
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... Signal transducing adaptor molecule has been shown to interact with STAMBP, HGS, TIMM8A and Janus kinase 2 ...
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