The P250 pistol is offered in three glass-reinforced polymer grip module sizes—small, medium, and large—in each of the full-sized, compact, and subcompact P250 variants. The pistol top ends also come in full-sized, compact, and subcompact variants that will fit the correspondingly sized grip modules. Every chambering can be converted by the user with a caliber exchange kit. The 9×19mm Parabellum, .40 S&W, and .357 SIG chamberings share their polymer grip frame modules and this offers the possibility to interchange these three chamberings by swapping the top end—consisting of the slide, recoil spring assembly, barrel and the box magazine. Due to the significantly larger external dimensions of the .45 ACP cartridge compared to the other P250 chambering options, the .45 ACP chambering uses slightly wider .45 ACP specific polymer grip modules with an enlarged magazine well.
The manufacturer offers caliber exchange kits or Caliber X-Change kits consisting of a slide, recoil assembly, barrel, box magazine and grip module in the varying frame sizes, grip module sizes and chambering variants in which the P250 pistol is offered. These kits enable a user to switch between the various P250 configurations without the use of tools.