Sialic Acid - Biosynthesis


In bacterial systems, sialic acids are biosynthesized by an aldolase enzyme. The enzyme uses a mannose derivative as a substrate, inserting three carbons from pyruvate into the resulting sialic acid structure. These enzymes can be used for chemoenzymatic synthesis of sialic acid derivatives.

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Other articles related to "biosynthesis":

Salinomycin - Biosynthesis
... A team from the University of Cambridge has cloned and sequenced the biosynthetic cluster responsible for salinomycin production, from Streptomyces albus DSM 41398 ... This has shown that the polyketide backbone of salinomycin is synthesised on an assembly line of nine polyketide synthase (PKS) multienzymes ...
... formation of metabolons Metabolic pathway Events supporting metabolon's formation DNA biosynthesis A, B, C, E, F RNA biosynthesis A, B, C, E, F Protein biosynthesis A, B, C, D ...
Thiostrepton - History
... Early in 1978, Bycroft and Gowland proposed the biosynthesis of thiostrepton, which was still unclear until 2009 ... Several studies of thiopeptide biosynthesis have been contemporarily published in 2009 and two of them (Liao et al ... and Kelly et al.) included the similar biosynthesis of thiostrepton it's ribosomally synthesized from thiostrepton biosynthetic genes (tsr genes) and posttranslational modification is ...

Biosynthesis (also called biogenesis or "anabolism") is an enzyme-catalyzed process in cells of living organisms by which substrates are converted to more complex products. The biosynthesis process often consists of several enzymatic steps in which the product of one step is used as substrate in the following step. Examples for such multi-step biosynthetic pathways are those for the production of amino acids, fatty acids, and natural products. Biosynthesis plays a major role in all cells, and many dedicated metabolic routes combined constitute general metabolism.

The prerequisites for biosynthesis are precursor compounds, chemical energy (such as in the form ATP), and catalytic enzymes, which may require reduction equivalents (e.g., in the form of NADH, NADPH).

Commonly known complex products of biosynthesis include proteins, vitamins, and antibiotics. Most organic compounds in living organisms are built in biosynthetic pathways.

Santonin - Proposed Biosynthesis
... The full biosynthesis of α-santonin has not been elucidated but α-santonin bears much similarity to parthenolide ... The proposed biosynthesis begins with the cyclization of farnesyl diphosphate (FPP) to (+)-germacrene A by a sesquiterpene synthase ...