Sialic Acid

Sialic acid is a generic term for the N- or O-substituted derivatives of neuraminic acid, a monosaccharide with a nine-carbon backbone. It is also the name for the most common member of this group, N-acetylneuraminic acid (Neu5Ac or NANA). Sialic acids are found widely distributed in animal tissues and to a lesser extent in other species, ranging from plants and fungi to yeasts and bacteria, mostly in glycoproteins and gangliosides. The amino group generally bears either an acetyl or glycolyl group, but other modifications have been described. The hydroxyl substituents may vary considerably; acetyl, lactyl, methyl, sulfate, and phosphate groups have been found. The term "sialic acid" (from the Greek for saliva, σίαλον/sialon) was first introduced by Swedish biochemist Gunnar Blix in 1952.

Read more about Sialic Acid:  Structure, Biosynthesis, Function

Other articles related to "sialic acid, sialic":

SIGLEC - Function - Signalling
... CD22 inhibition of BCR signalling was originally thought to be sialic acid-binding-independent, but evidence suggests α2,6 sialic acid ligands are required for inhibition ... leads to cellular inactivation once bound to its sialic acid-containing cognate ligand and is found in high levels on NK cell surfaces ... Mammalian cells contain high levels of sialic acid and so when NK cells bind so called "self-cells", they are not activated and do not kill host cells ...
Complement Control Protein - Mechanisms of Protection
... Factor H can bind C3b much more easily in the presence of sialic acid, which is a component of most cells in the human body conversely, in the absence of sialic ... is bound to a "self" cell, the presence of sialic acid and the binding of factor H will prevent the complement cascade from activating if C3b is bound to a bacterium, factor B will bind and the cascade will be set ...
ST8SIA1
... Gangliosides are membrane-bound glycosphingolipids containing sialic acid ... encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3 ...
Infantile Free Sialic Acid Storage Disease
... Infantile free sialic acid storage disease (ISSD) is a lysosomal storage disease caused when sialic acid, a kind of charged sugar, is unable to be transported out of the lysosomal membrane ... member 50) gene cause all forms of sialic acid storage disease ... ISSD is the most severe form of the sialic acid storage diseases ...
Sialic Acid - Function
... Sialic acid-rich glycoproteins (sialoglycoproteins) bind selectin in humans and other organisms ... Metastatic cancer cells often express a high density of sialic acid-rich glycoproteins ... This overexpression of sialic acid on surfaces creates a negative charge on cell membranes ...