Sialic

Some articles on sialic:

Sialoadhesin
... Sialoadhesin binds to certain molecules called sialic acids ... v-set domain to the 3'-sialyllactose) and the carboxylate group of the sialic acid ... Since sialoadhesin binds sialic acids with its N-terminal IgV-domain, it is also a member of the SIGLEC family ...
SIGLEC - Structure - Ligand Binding
... Due to the acidic nature of sialic acid, Siglec active sites contain a conserved arginine residue which is positively charged at physiological pH ... Sialoadhesin, where arginine at position 97 forms salt bridges with the COO- group of the sialic acid, producing a stable interaction ... lectin domain is specific for the linkage that connects sialic acid to the glycan ...
Complement Control Protein - Mechanisms of Protection
... Factor H can bind C3b much more easily in the presence of sialic acid, which is a component of most cells in the human body conversely, in the ... This means that if C3b is bound to a "self" cell, the presence of sialic acid and the binding of factor H will prevent the complement cascade from activating if C3b is bound to a ...
Sialic Acid-binding Ig-like Lectin 12
... Sialic acid-binding Ig-like lectin 12 is a protein that in humans is encoded by the SIGLEC12 gene ... Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily ... by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins ...
Sialic Acid - Biosynthesis
... In bacterial systems, sialic acids are biosynthesized by an aldolase enzyme ... three carbons from pyruvate into the resulting sialic acid structure ... be used for chemoenzymatic synthesis of sialic acid derivatives ...