Si DNA - Possible Therapeutic Application

Possible Therapeutic Application

Most of the anticancer therapies act by induction of DNA damage (chemotherapy and radiation therapy). DNA breaks are the most lethal damage for cells, as one single double-strand break if unrepaired is sufficient to lead to cell death. Dbait enhances the efficacy of the DNA damaging agents as demonstrated with radiation therapy and/or chemotherapy in multiple in vivo experimental models such as melanoma, glioblastoma and colorectal cancer. Preclinical proof of concept of the synergic effect of the clinical candidate, DT01, with radiation therapy lead to a first-in-human Phase I, which is currently underway to evaluate the tolerance and efficacy of local DT01 administration in association with RT in patients suffering from in-transit metastases of melanoma.

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Famous quotes containing the words application and/or therapeutic:

    May my application so close
    To so endless a repetition
    Not make me tired and morose
    And resentful of man’s condition.
    Robert Frost (1874–1963)

    As a science of the unconscious it is a therapeutic method, in the grand style, a method overarching the individual case. Call this, if you choose, a poet’s utopia.
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