Possible Therapeutic Application
Most of the anticancer therapies act by induction of DNA damage (chemotherapy and radiation therapy). DNA breaks are the most lethal damage for cells, as one single double-strand break if unrepaired is sufficient to lead to cell death. Dbait enhances the efficacy of the DNA damaging agents as demonstrated with radiation therapy and/or chemotherapy in multiple in vivo experimental models such as melanoma, glioblastoma and colorectal cancer. Preclinical proof of concept of the synergic effect of the clinical candidate, DT01, with radiation therapy lead to a first-in-human Phase I, which is currently underway to evaluate the tolerance and efficacy of local DT01 administration in association with RT in patients suffering from in-transit metastases of melanoma.
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Other articles related to "therapeutic":
... Moreno and expressive media for therapeutic acting-out, as well as the procedures of Buddhist insight meditation (satipatthána-vipassaná) and satidrama for therapeutic acting-i ... Thus the format of satitherapy includes theoretical knowledge and therapeutic skills from both Western and Asian sources ...
... in line with the studied effects of other κ-opioid agonists, may have further therapeutic potential ... against cancer and HIV At the present time, there are a lot of therapeutic targets that have many people excited ... scheduling salvia could scare away a great deal of research and development into salvia's therapeutic promise ...
... raised against use of the term Moralistic Therapeutic Deism ... One critic states that, "the 'religion' called Moralistic Therapeutic Deism would be more accurately called Moralistic Therapeutic Theism ... There is no reason to invent the phrase Moralistic Therapeutic Deism to begin with—because it is, as has already been stated many times, merely a diluted version of the ...
... A Therapeutic Garden is an outdoor garden space that has been specifically designed to meet the physical, psychological, social and spiritual needs of the ... Therapeutic Gardens can be found in a variety of settings, including but not limited to hospitals, skilled nursing homes, assisted living residences, continuing care retirement communities ...
... Therapeutic misconception is a common ethical problem encountered in human subjects research ... in 1987 was the following “To maintain a therapeutic misconception is to deny the possibility that there may be major disadvantages to participating in clinical ...
Famous quotes containing the words application and/or therapeutic:
“May my application so close
To so endless a repetition
Not make me tired and morose
And resentful of mans condition.”
—Robert Frost (18741963)
“As a science of the unconscious it is a therapeutic method, in the grand style, a method overarching the individual case. Call this, if you choose, a poets utopia.”
—Thomas Mann (18751955)