Secretase

  • (noun): A set of enzymes believed to snip pieces off a longer protein producing fragments of amyloid protein that bunch up and create amyloid protein plaques in brain tissue (the pathological hallmark of Alzheimer's).

Some articles on secretase, secretases:

Gamma Secretase
... Gamma secretase is a multi-subunit protease complex, itself an integral membrane protein, that cleaves single-pass transmembrane proteins at residues within the transmembrane domain ... The most well-known substrate of gamma secretase is amyloid precursor protein, a large integral membrane protein that, when cleaved by both gamma and beta secretase, produces a short 17-42 amino acid ... Gamma secretase is also critical in the related processing of the Notch protein ...
Amyloid Precursor Protein Secretase
... Secretases are enzymes that "snip" pieces off a longer protein that is embedded in the cell membrane ... Among other roles in the cell, secretases act on the amyloid precursor protein (APP) to cleave the protein into three fragments ... Sequential cleavage by β-secretase (BACE) and γ-secretase produces the amyloid-β peptide fragment that aggregates into clumps called "plaques" in the brains of Alzheimer's ...
Early-onset Alzheimer's Disease - Familial Alzheimer's Disease - Pathophysiology
... Following cleavage by β-secretase, APP is cleaved by a membrane-bound protein complex called γ-secretase to generate Aβ ... Alpha-secretase cleavage of APP, which precludes the production of Aβ, is the most common processing event for APP ...
TMED10
... The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity ...
Alzheimer's Disease Clinical Research - Treatments in Clinical Development - Immunotherapy To Amyloid Beta - Gamma Secretase Inhibition
... Gamma secretase is a protein complex thought to be a fundamental building block in the development of the amyloid beta peptide ... A gamma secretase inhibitor known as LY451039 is in Phase 3 trials ...