Schnitzler Syndrome - Diagnosis

Diagnosis

Blood tests show a high concentration of specific gamma-globulins (monoclonal gammopathy) of the IgM type. It almost always has light chains of the κ-type. A variant in which IgG is raised has been described, which appears to be ten times as rare. The immunoglobulins may show up in the urine as Bence Jones proteins. Signs of inflammation are often present: these include an increased white blood cell count (leukocytosis) and a raised erythrocyte sedimentation rate and C-reactive protein. There can be anemia of chronic disease. Bone abnormalities can be seen on radiological imaging (often increased density or osteosclerosis) or biopsy.

Because it is such a rare condition (less than 100 cases reported in the literature worldwide before 2008), it is important to rule out other conditions which can cause periodic fevers, paraproteins or chronic hives. These include (and are not limited to) auto-immune or -inflammatory disorders such as adult-onset Still's disease, angioedema, hematological disorders such as lymphoma or monoclonal gammopathy of undetermined significance, other causes of hives, cryoglobulinemia, mastocytosis, chronic neonatal onset multisystem inflammatory disease or Muckle-Wells syndrome. It is however possible to have more than one rare condition as seen by a patient with Schnitzler's syndrome and cold induced urticaria.

Read more about this topic:  Schnitzler Syndrome

Other articles related to "diagnosis":

Major Diagnostic Category
... principal diagnoses (from ICD-9-CM) into 25 mutually exclusive diagnosis areas ... are assigned to MDC 24 (Multiple Significant Trauma) with at least two significant trauma diagnosis codes (either as principal or secondaries) from different body site categories ... Patients assigned to MDC 25 (HIV Infections) must have a principal diagnosis of an HIV Infection or a principal diagnosis of a significant HIV related condition and a ...
Sexual Fetishism - Modern Theory and Treatment - Diagnosis
... It is sufficient for the diagnosis if one of the participants is being hurt or mistreated in any other way ... A correct diagnosis in terms of the ICD manual stipulates hierarchical proceeding ... Still today, arguments go on whether a specific diagnosis fetishism is needed at all or if paraphilia as such is sufficient ...
Pheochromocytoma - Diagnosis
... The diagnosis can be established by measuring catecholamines and metanephrines in plasma (blood) or through a 24-hour urine collection ...
Rosenhan Experiment - Impact and Controversy
... his findings in Science, criticizing the reliability of psychiatric diagnosis and the disempowering and demeaning nature of patient care experienced by ... Many defended psychiatry, arguing that as psychiatric diagnosis relies largely on the patient's report of their experiences, faking their presence no more demonstrates problems ...
Taser - Excited Delirium
... See also Taser safety issues Some of the deaths associated with tasers are given a diagnosis of excited delirium, a term for a phenomenon that manifests ... The diagnosis of excited delirium has been controversial ... examiners for several years, mainly as a diagnosis of exclusion established on autopsy ...