RUNX3

RUNX3

Identifiers Symbols RUNX3; AML2; CBFA3; PEBP2aC External IDs OMIM: 600210 MGI: 102672 HomoloGene: 37914 GeneCards: RUNX3 Gene

Gene Ontology
Molecular function RNA polymerase II regulatory region sequence-specific DNA binding
sequence-specific DNA binding RNA polymerase II transcription factor activity
sequence-specific DNA binding transcription factor activity
protein binding
ATP binding
Cellular component nuclear chromatin
nucleus
cytoplasm
Biological process negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-dependent
transcription from RNA polymerase II promoter
protein phosphorylation
induction of apoptosis
axon guidance
hair follicle morphogenesis
interferon-gamma production
negative regulation of cell cycle
cell maturation
peripheral nervous system neuron development
negative regulation of epithelial cell proliferation
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 864 12399 Ensembl ENSG00000020633 ENSMUSG00000070691 UniProt Q13761 Q64131 RefSeq (mRNA) NM_001031680 NM_019732 RefSeq (protein) NP_001026850 NP_062706 Location (UCSC) Chr 1:
25.23 – 25.29 Mb Chr 4:
135.12 – 135.18 Mb PubMed search

Runt-related transcription factor 3 is a protein that in humans is encoded by the RUNX3 gene.

This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-YGYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

In melanocytic cells RUNX3 gene expression may be regulated by MITF.

Read more about RUNX3:  Knockout Mouse, Interactions, See Also