|Molecular function||• RNA polymerase II regulatory region sequence-specific DNA binding
• sequence-specific DNA binding RNA polymerase II transcription factor activity
• sequence-specific DNA binding transcription factor activity
• protein binding
• ATP binding
|Cellular component||• nuclear chromatin
|Biological process||• negative regulation of transcription from RNA polymerase II promoter
• regulation of transcription, DNA-dependent
• transcription from RNA polymerase II promoter
• protein phosphorylation
• induction of apoptosis
• axon guidance
• hair follicle morphogenesis
• interferon-gamma production
• negative regulation of cell cycle
• cell maturation
• peripheral nervous system neuron development
• negative regulation of epithelial cell proliferation
|Sources: Amigo / QuickGO|
25.23 – 25.29 Mb
135.12 – 135.18 Mb
Runt-related transcription factor 3 is a protein that in humans is encoded by the RUNX3 gene.
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-YGYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
In melanocytic cells RUNX3 gene expression may be regulated by MITF.