Ribavirin

Ribavirin (brand names: Copegus, Rebetol, Ribasphere, Vilona, and Virazole) is an anti-viral drug indicated for severe RSV infection (individually), hepatitis C infection (used in conjunction with peginterferon alfa-2b or peginterferon alfa-2a), and other viral infections. Ribavirin is a prodrug, which when metabolized resembles purine RNA nucleotides. In this form it interferes with RNA metabolism required for viral replication. How it exactly affects viral replication is unknown; many mechanisms have been proposed for this (see Mechanisms of Action, below) but none of these has been proven to date. Multiple mechanisms may be responsible for its actions.

The primary observed serious adverse side effect of ribavirin is hemolytic anemia, which may worsen preexisting cardiac disease. The mechanism for this effect is due to ribavarin's buildup inside erythrocytes. Oxidative damage to erythrocyte cell membrane is usually inhibited by glutathione; however, with reduced ATP levels caused by ribavirin, glutathione levels are impaired, permitting oxidative erythrocyte cell lysis. The gradual loss of erythrocytes leads to anemia. The anemia is dose-dependent and may sometimes be compensated by decreasing dose. Ribavirin is also a teratogen in some animals species and thus poses a theoretical reproductive risk in humans, remaining a hazard as long as the drug is present, which can be as long as 6 months after a course of the drug has ended.

Read more about Ribavirin:  Uses, Marketing, History, Chemistry, Derivatives, Pharmacokinetics, Adverse Effects

Other articles related to "ribavirin":

Taribavirin
... It is a prodrug of ribavirin, active against a number of DNA and RNA viruses ... Taribavirin has better liver-targeting than ribavirin, and has a shorter life in the body due to less penetration and storage in red blood cells ... eventually to be the drug of choice for viral hepatitis syndromes in which ribavirin is active ...
Ribavirin - Adverse Effects
... Ribavirin is not substantially incorporated into DNA, but does have a dose-dependent inhibiting effect on DNA synthesis, as well as having other effects on ... significant teratogenic effects have been noted in all non-primate animal species on which ribavirin has been tested ... Ribavirin did not produce birth defects in baboons, but this should not be an indication that it is safe in humans ...
Suppression of Glial Scar Formation - Ribavirin
... Ribavirin is a purine nucleoside analogue that is generally used as an anti-viral medication ...
Boceprevir - Clinical Trials - RESPOND-2 Trial
... not have a sustained response to therapy with peginterferon-ribavirin therapy ... All patients received a month of peg-interferon alfa-2b and ribavirin before being randomized to one of three arms ... The first arm received placebo plus peginterferon-ribavirin for 44 weeks ...
Hepatitis C And HIV Co-infection - Treatment
... Currently, peginterferon alfa-2a plus ribavirin is the only FDA approved treatment for HIV–HCV co-infected patients ... Ribavirin is a synthetic nucleoside analogue, but its mechanism of action is not clearly established ... Ribavirin inhibits the replication of a wide range of RNA and DNA viruses ...