|Molecular function||• protein binding
|Cellular component||• nucleoplasm
• NuRD complex
• ESC/E(Z) complex
|Biological process||• negative regulation of transcription from RNA polymerase II promoter
• DNA replication
• nucleosome assembly
• transcription, DNA-dependent
• multicellular organismal development
• cell proliferation
• negative regulation of cell growth
• CENP-A containing nucleosome assembly at centromere
• cellular heat acclimation
|Sources: Amigo / QuickGO|
16.86 – 16.89 Mb
162.76 – 162.78 Mb
Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene.
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.
Other articles related to "rbbp7":
... RBBP7 has been shown to interact with HDAC1, MTA2, SIN3A, Retinoblastoma protein, SAP30, GATAD2B and BRCA1 ...