RBBP7

RBBP7

Identifiers Symbols RBBP7; RbAp46 External IDs OMIM: 300825 MGI: 1194910 HomoloGene: 55702 GeneCards: RBBP7 Gene

Gene Ontology
Molecular function protein binding
Cellular component nucleoplasm
NuRD complex
ESC/E(Z) complex
Biological process negative regulation of transcription from RNA polymerase II promoter
DNA replication
nucleosome assembly
transcription, DNA-dependent
multicellular organismal development
cell proliferation
negative regulation of cell growth
CENP-A containing nucleosome assembly at centromere
cellular heat acclimation
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5931 245688 Ensembl ENSG00000102054 ENSMUSG00000031353 UniProt Q16576 Q60973 RefSeq (mRNA) NM_001198719 NM_009031 RefSeq (protein) NP_001185648 NP_033057 Location (UCSC) Chr X:
16.86 – 16.89 Mb Chr X:
162.76 – 162.78 Mb PubMed search

Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene.

This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.

Read more about RBBP7:  Model Organisms, Interactions

Other articles related to "rbbp7":

RBBP7 - Interactions
... RBBP7 has been shown to interact with HDAC1, MTA2, SIN3A, Retinoblastoma protein, SAP30, GATAD2B and BRCA1 ...