Protein Folding

Protein folding is the process by which a protein structure assumes its functional shape or conformation. It is the physical process by which a polypeptide folds into its characteristic and functional three-dimensional structure from random coil. Each protein exists as an unfolded polypeptide or random coil when translated from a sequence of mRNA to a linear chain of amino acids. This polypeptide lacks any developed three-dimensional structure (the left hand side of the neighboring figure). Amino acids interact with each other to produce a well-defined three-dimensional structure, the folded protein (the right hand side of the figure), known as the native state. The resulting three-dimensional structure is determined by the amino acid sequence (Anfinsen's dogma).

The correct three-dimensional structure is essential to function, although some parts of functional proteins may remain unfolded. Failure to fold into native structure produces inactive proteins that are usually toxic. Several neurodegenerative and other diseases are believed to result from the accumulation of amyloid fibrils formed by misfolded proteins. Many allergies are caused by the folding of the proteins, for the immune system does not produce antibodies for certain protein structures.

Read more about Protein FoldingExperimental Techniques For Studying Protein Folding

Other articles related to "folding, protein folding, protein":

Life With Play Station - Channels - Folding@Home
... Life with PlayStation also hosted an application for Folding@home, a distributed computing project for disease research that simulates protein folding and. 2006, Stanford University announced that a protein folding client would be available to run on the PS3 ... Gamers were able to contribute to the project by leaving their client to run Folding@home while not playing games ...
Computational Methods For Studying Protein Folding - Modeling of Protein Folding
... De novo or ab initio techniques for computational protein structure prediction are related to, but strictly distinct from experimental studies of protein folding ... Dynamics (MD) is an important tool for studying protein folding and dynamics in silico ... First equilibrium folding simulations were done using implicit solvent model and umbrella sampling ...
Arthur L. Horwich - Awards and Honors
... fundamental discoveries concerning chaperone assisted protein folding in the cell and its relevance to neurodegeneration" ... of the Max Planck Institute of Biochemistry, "for their significant contribution in protein folding." He received the 2008 Lewis S ... Hartl "for their pioneering work in the field of protein-mediated protein folding." Also with Hartl, Horwich received the 2008 Louisa Gross Horwitz Prize for Biology or Biochemistry from ...
Paul Chun (professor)
... He is a researcher in the field of protein folding equilibria, in particular, he is known as the "leading proponent" of using the Planck-Benzinger thermal work function to understand protein ... As such Chun has written a number of papers relating to the thermodynamics of protein folding ...
FKBP1A
... receptor binding • ryanodine-sensitive calcium-release channel activity • protein binding • macrolide binding • FK506 binding • type I transforming growth factor ... The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding ... This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin ...

Famous quotes containing the words folding and/or protein:

    A little sleep, a little slumber, a little folding of the hands to rest, and poverty will come upon you like a robber, and want, like an armed warrior.
    Bible: Hebrew, Proverbs 6:10.

    Firm-style bean curd insoles cushion feet, absorb perspiration and provide more protein than meat or fish innersoles of twice the weight. Tofu compresses with use, becoming more pungent and flavorful. May be removed when not in use to dry or marinate. Innersoles are ready to eat after 1,200 miles of wear. Each pair provides adult protein requirement for 2 meals. Insoles are sized large to allow for snacks. Recipe booklet included.
    Alfred Gingold, U.S. humorist. Items From Our Catalogue, “Tofu Innersoles,” Avon Books (1982)