PHD Finger

The PHD finger (Plant Homeo Domain) was discovered in 1993 as a Cys4-His-Cys3 motif in the homeodomain protein HAT3 in Arabidopsis thaliana. The PHD finger motif resembles the metal binding RING domain (Cys3-His-Cys4) and FYVE domain. It occurs as a single finger, but often in clusters of two or three, and it also occurs together with other domains, such as the chromodomain and the bromodomain.

Read more about PHD FingerPHD Finger in Proteins Related To Epigenetics, Structure Data On The PHD Finger, Function of The PHD Finger

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Function of The PHD Finger
... Recently the PHD fingers of some proteins, including ING2, YNG1 and NURF, have been reported to bind to histone H3 tri-methylated on lysine 4 (H3K4me3), while other PHD fingers have tested negative in ... Interestingly, a protein called SMCX (or JARID1C) has a PHD finger, which has been reported to bind histone H3 tri-methylated lysine 9 (H3K9me3) ... binding to tri-methylated lysines on histones may therefore be a property widespread among PHD fingers ...

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