Pcna

Some articles on pcna:

Proliferating Cell Nuclear Antigen - External Links
... PCNA at the US National Library of Medicine Medical Subject Headings (MeSH) "ANA Cell cycle related (Mitotic) PCNA type 1 and type 2 Antibody Patterns" ... Retrieved 2008-04-15 "Movie showing a model of clamp loading of PCNA onto DNA" ...
DNA Clamp - Structure
... and eukaryotes, it is a trimer composed of three molecules of PCNA ... gp45 that is a trimer similar in structure to PCNA but lacks sequence homology to either PCNA or the bacterial beta clamp ... III dimer DNA polymerase III Archaea archaeal PCNA trimer pol ε Eukaryote PCNA trimer DNA polymerase delta Virus gp43 / gp45 trimer RB69 Pol / T4 Pol ...
DNA Mismatch Repair - Mismatch Repair Proteins - β-sliding Clamp/PCNA
... PCNA and the β-sliding clamp associate with MutSα/β and MutS, respectively ... Although initial reports suggested that the PCNA-MutSα complex may enhance mismatch recognition, it has been recently demonstrated that there is no apparent change in affinity ... mutants of MutSα that are unable to interact with PCNA in vitro exhibit the capacity to carry out mismatch recognition and mismatch excision to near wild type levels ...
Proliferating Cell Nuclear Antigen - Expression in The Nucleus During DNA Synthesis
... PCNA was originally identified as an antigen that is expressed in the nuclei of cells during the DNA synthesis phase of the cell cycle ... PCNA helps hold DNA polymerase delta (Pol δ) to DNA ... PCNA is clamped to DNA through the action of replication factor C (RFC), which is a heteropentameric member of the AAA+ class of ATPases ...
Proliferating Cell Nuclear Antigen - Role in DNA Repair
... resynthesis of excised damaged DNA strands during DNA repair, PCNA is important for both DNA synthesis and DNA repair ... PCNA is also involved in the DNA damage tolerance pathway known as post-replication repair (PRR) ... PCNA is pivotal to the activation of these pathways and the choice as to which pathway is utilised by the cell ...