PARP1 - Function


PARP1 works:

  • By modifying nuclear proteins by poly ADP-ribosylation.
  • In conjunction with BRCA, which acts on double strands; members of the PARP family act on single strands; or, when BRCA fails, PARP takes over those jobs as well.

PARP1 is involved in:

  • Differentiation, proliferation, and tumor transformation
  • Normal or abnormal recovery from DNA damage
  • May be the site of mutation in Fanconi anemia
  • May participate in the pathophysiology of type I diabetes.

PARP1 is activated by:

  • Helicobacter pylori in the development and proliferation of gastric cancer.

Read more about this topic:  PARP1

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Integral - Fundamental Theorem of Calculus
... and integration are inverse operations if a continuous function is first integrated and then differentiated, the original function is retrieved ... to compute integrals by using an antiderivative of the function to be integrated ...
Integral - Extensions - Multiple Integration
... In general, an integral over a set E of a function f is written Here x need not be a real number, but can be another suitable quantity, for instance, a vector ... Just as the definite integral of a positive function of one variable represents the area of the region between the graph of the function and the x-axis, the double integral of a positive function of two variables ... same volume can be obtained via the triple integral — the integral of a function in three variables — of the constant function f(x, y, z) = 1 over the above ...

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